CC BY-NC-ND 4.0 · Ann Natl Acad Med Sci 2018; 54(03): 171-174
DOI: 10.1055/s-0040-1712843
Case Report

Reverse 'Hot Cross Bun' Sign in Primary Progressive Aphasia - An Atypical MRI Feature

Rajendra Singh Jain
Department of Neurology, Sawai Man Singh Medical College, Jaipur, Rajasthan
,
Kamlesh Kumar
Department of Neurology, Sawai Man Singh Medical College, Jaipur, Rajasthan
,
Ashwini Hiremath
Department of Neurology, Sawai Man Singh Medical College, Jaipur, Rajasthan
› Author Affiliations

Source of Funding None.

ABSTRACT

Primary progressive aphasia (PPA) is thought to be a disorder of focal cortical degeneration which occurs as a result of lobar atrophy of dominant frontal and temporal lobe. We report a case of a 78 year old male patient presenting with progressive language affection predominantly and clinically diagnosed as PPA but magnetic resonance imaging (MRI) brain showed an unusual finding of reverse 'hot cross bun' sign in pons in T2 weighted (T2W) / diffusion weighted image (DWI)/ T2 fluid attenuated inversion recovery (FLAIR) axial views. This is the first case report of reverse 'hot cross bun' sign in a case of PPA to the best of our knowledge.



Publication History

Article published online:
09 May 2020

© .

Thieme Medical and Scientific Publishers Private Ltd.
A-12, Second Floor, Sector -2, NOIDA -201301, India

 
  • References

  • 1 Grossman M, Mickanin J, Onishi K, et al (1996). Progressive non-fluent aphasia: language, cognitive and PET measures contrasted with probable Alzheimer's disease. J Cogn Neurosci 8: 135–154.
  • 2 Mesulam MM (2001). Primary progressive aphasia. Ann Neurol 49: 425– 432.
  • 3 Nagpal K, Agarwal P (2017). “Hot-cross bun” and “inverse trident sign” in neurosarcoidosis: an important finding. Neurol India 65: 175-176.
  • 4 Jain RS, Sannegowda RB, Jain R, et al (2014). Reverse 'hot cross bun', 'Mercedes Benz', 'face of the giant panda and her cub' signs with pontine infarcts: a radiological Pandora. Br Med J Case Rep 5: 32.
  • 5 Jain RS, Khan I, Khandelwal K, Sharma M (2017). Neuroimage: “Hot cross bun” sign (reverse) in case of Wilson disease. J N eu ro l Ne u rop hysi ol 8: i1 07 . doi:10.4172/2155-9562.1000i107.