Download PDF
CC BY-NC-ND 4.0 · Ann Natl Acad Med Sci 2016; 52(01): 029-038
DOI: 10.1055/s-0040-1712605
Original Article

Vitiligo – An Indian Perspective

A. J. Kanwar
Professor & Head, Department of Dermatology School of Medical Sciences and Research, Sharda Hospital, Greater Noida
› Author Affiliations
› Further Information
  PDF Download Permissions and Reprints

SUMMARY

The prevalence of vitiligo in India is high. It affects DLQI. Exact aetiology is not clear. Melanocytorrhagy hypothesis is important. Classification into segmental and non segmental vitiligo is satisfactory from prognosis and treatment point of view. Onset of vitiligo after the age of 30 years is defined as late onset vitiligo: separate subset with strong genetic background and presence of precipitating environmental factors. Mucosal vitiligo is a distinct subset. Koebner type 2A phenomenon needs redefining.

Oral minipulse and minocycline are effective in progressive unstable vitiligo. Narrowband UVB phototherapy is effective in both children and adults: it has an edge over PUVA. NCECS is the most common surgical technique used in treatment. Suspension in patient's serum gives better results. NCECS is better than SEBG. Camouflaging and depigmentation are required in some cases.

DR. R.V. RAJAM ORATION delivered during NAMSCON 2014 at the All-India Institute of Medical Sciences, Rishikesh.




Publication History

Article published online:
09 May 2020

© .

Thieme Medical and Scientific Publishers Private Ltd.
A-12, Second Floor, Sector -2, NOIDA -201301, India

 

  • REFERENCES

  • 1 1. Kumar R, Parsad D, Kanwar AJ (2011). Role of apoptosis and melanocytorrhagy; a comparative study of melanocyte adhesion in stable and unstable vitiligo. Brit J Dermatol 164:187-191.
  • 2 Kumar R, Parsad D, Kanwar AJ, Kaul D (2012). Altered levels of LXR-alpha: crucial implications in the pathogenesis of vitiligo. Exptl Dermatol 21:853-858.
  • 3 Kanwar AJ, Mahajan R, Parsad D (2013). Effect of age at onset on disease characteristics in vitiligo. J Cut Med Surg 17:253-258.
  • 4 Kanwar AJ, Parsad D, De D (2011). Mucosal involvement in vitiligo: comprehensive review of 241 cases. J Eur Acad Dermatol Venereol 25:1360-1366.
  • 5 Kanwar AJ, Mahajan R, Parsad D (2013). Koebner's phenomenon in vitiligo in Indian population. Clin Exptl Dermatol 38:553-558.
  • 6 Kanwar AJ, Mahajan R, Parsad D (2014). Type 2 A Koebner phenomenon in vitiligo is distinct from other subtypes: observations from an Indian cohort. Brit J Dermatol 170 : 586-590.
  • 7 Kanwar AJ, Mahajan R, Parsad D (2013). Low dose oral minipulse therapy in progressive unstable vitiligo. J Cut Med Surg 17:259-268.
  • 8 Parsad D, Kanwar AJ (2010). Oral minocycline in the treatment of vitiligo--a preliminary study. Dermatologic Therapy 23:305-307.
  • 9 Grimes PE, Soariano T, Dytoc MT (2002). Topical tacrolimus for repigmentation of vitiligo. J Am Acad Dermatol 47:789-791.
  • 10 Kanwar AJ, Dogra S, Parsad D (2004). Topical; tacrolimus for treatment of childhood vitiligo in Asians. Clin Exptl Dermatol 29:589 - 592.
  • 11 Kanwar AJ, Dogra S, Parsad D, Kumar B (2005). Narrowband UVB for treatment of vitiligo: an emerging effective and well tolerated therapy. Int J Dermatol 44:57-60.
  • 12 Kanwar AJ, Dogra S (2005). Narrow band UVB for treatment of generalized vitiligo in children. Clin Exptl Dermatol 30:332-336
  • 13 Bhatnagar A, Kanwar AJ, Parsad D, De D (2007). Comparison of systemic PUVA and narrow band UVB in the treatment of vitiligo: an open prospective study. J Eur Acad Dermatol Venereol 21:638-642
  • 14 Gauthier Y, Surleve-Bazeille Y(1992). Autologous grafting with non cultured melanocytes: a simplified method for treatment of depigmented lesions. J Am Acad Dermatol 26:191-194.
  • 15 Olsson MJ, Juhlin (2002). Long term follow up of leucoderma patients treated witautologous cultured melanocytes, ultra thin epidermal sheets and basal cell layer suspension. Brit J Dermatol 1247:893-904.
  • 16 Holla A, Sahni K, Kumar R, Parsad D, Kanwar AJ, Mehta SD (2012). Acral vitiligo and lesions over joints treated with non cultured epidermal cell suspension transplantation. Clin Exptl Dermatol 41:23-25.
  • 17 Sahni K, Parsad D, Kanwar AJ, Mehta SD (2011). Autologous non cultured melanocyte transplantation for stable vitiligo: can suspending autologous melanocytes in the patients' own serum improve repigmentation and patient satisfaction? Dermatol Surg 37:176-182.
  • 18 Hola AP, Sahni K, Kumar R, Kanwar AJ, Mehta SD, Parsad D (2013). Repigmentation of leucotrichia due to retrograde migr a tion of melanocytes after non cultured epidermal suspension transplantation. Dermatol Surg 28:1-7.
  • 19 Budania A, Parsad D, Kanwar AJ, Dogra S (2012). Comparison between autologous non cultured epidermal cell suspension and suction blister epidermal grafting in suction blister epidermal grafting in stable vitiligo: a randomized study. Brit J Dermatol 167:1295-1301.
  • 20 Singh C, Parsad D, Kanwar AJ, Kumar R (2013). Comparison between autologous non cultured extracted hair follicle outer root sheath cell suspension and autologous non cultured epidermal cell suspension in treatment of stable vitiligo: a randomized study. Brit J Dermatol 169:298 -305.