Download PDF
CC BY 4.0 · Rev Bras Ginecol Obstet 2020; 42(06): 365-368
DOI: 10.1055/s-0040-1712485
Case Report
Thieme Revinter Publicações Ltda Rio de Janeiro, Brazil

Cellular Angiofibroma: A Rare Vulvar Tumor Case Report

Angiofibroma celular: Um caso raro de tumor vulvar
Ana Helena Barbosa Fachada 
1   Gynecology and Obstetrics Department, Centro Hospitalar Tondela-Viseu, Viseu, Portugal
,
Cátia Sofia Guilherme Ferreira Pais 
1   Gynecology and Obstetrics Department, Centro Hospitalar Tondela-Viseu, Viseu, Portugal
,
Marta Andrea Ferreira Fernandes 
1   Gynecology and Obstetrics Department, Centro Hospitalar Tondela-Viseu, Viseu, Portugal
,
Nuno Jorge Lopes Dias 
2   Anatomic Pathology Department, Centro Hospitalar Tondela-Viseu, Viseu, Portugal
,
António Manuel Leitão Loureiro Pipa 
1   Gynecology and Obstetrics Department, Centro Hospitalar Tondela-Viseu, Viseu, Portugal
› Author Affiliations
Further Information

Publication History

20 December 2019

30 March 2020

Publication Date:
30 June 2020 (online)

   Permissions and Reprints

Abstract

Cellular angiofibroma (CA)is a rare benign mesenchymal tumor. In women, it occurs mainly in the vulvovaginal region, with vulvar location in 70% of the cases. Its clinical presentation is nonspecific and similar to several other vulvar tumors of different cellular origins. Thus, its histological and immunohistochemical features allow distinction from other tumors. Cellular angiofibromas have good prognosis, despite some risk of relapse. The authors present the case of a 49-year-old woman with a bulky right vulvar lesion, for which the preoperative diagnosis was a Bartholin cyst, but the histological and immunohistochemical evaluation yielded a CA.

Resumo

O angiofibroma celular é um tumor mesenquimatoso benigno e raro. Nas mulheres, surge principalmente na região vulvo-vaginal, com localização vulvar em 70% dos casos. A sua apresentação clínica é inespecífica e semelhante a vários outros tumores vulvares de diferentes origens celulares. Assim, são as suas características histológicas e imunohistoquímicas que permitem a diferenciação entre eles. Os angiofibromas celulares têm bom prognóstico, embora apresentem algum risco de recidiva. Os autores apresentam o caso de uma mulher de 49 anos de idade com uma lesão vulvar direita volumosa, cujo diagnóstico pré-operatório era de quisto da glândula de Bartholin, mas cujo exame histológico e imunohistoquímico revelaram tratar-se de um angiofibroma celular.

Keywords

cellular angiofibroma - mesenchymal tumor - vulva

Palavras-chave

angiofibroma celular - tumor mesenquimatoso - vulva
 

  • References

  • 1 Nucci MR, Granter SR, Fletcher CD. Cellular angiofibroma: a benign neoplasm distinct from angiomyofibroblastoma and spindle cell lipoma. Am J Surg Pathol 1997; 21 (06) 636-644 . Doi: 10.1097/00000478-199706000-00002
    CrossrefPubMedGoogle Scholar
  • 2 Castro Herrera MD, Toribio Gutiérrez I, Serra Cansio E. Angiofibroma celular vulvar: (caso clínico y revisión). Rev Med Costa Rica Centroam. 2011; 68 (598) 307-309
    PubMedGoogle Scholar
  • 3 Guzmán Muñoz M, Delgado JJ, Ramos P, Heron S, Martínez-Parrondo N, Cano A, Zapico A. Angiofibroma celular de vulva: una entidad a investigar. Clin Invest Ginecol Obstet 2012; 39 (06) 265-267 . Doi: 10.1016/j.gine.2012.03.005
    PubMedGoogle Scholar
  • 4 Mandato VD, Santagni S, Cavazza A, Aguzzoli L, Abrate M, La Sala GB. Cellular angiofibroma in women: a review of the literature. Diagn Pathol 2015; 10: 114 . Doi: 10.1186/s13000-015-0361-6
    CrossrefPubMedGoogle Scholar
  • 5 Brandão A, Campos S, Fraga J, Silva T, Águas F. Angiofibroma celular em ginecologia: uma entidade rara na ginecologia. Acta Med Port 2017; 30 (12) 882-886 . Doi: 10.20344/amp.8774
    CrossrefPubMedGoogle Scholar
  • 6 Khmou M, Lamalmi N, Malihy A, Rouas L, Alhamany Z. Cellular angiofibroma of the vulva: a poorly known entity, a case report and literature review. BMC Clin Pathol 2016; 16: 8 . Doi: 10.1186/s12907-016-0030-z
    CrossrefPubMedGoogle Scholar
  • 7 Kerkuta R, Kennedy CM, Benda JA, Galask RP. Vulvar cellular angiofibroma: a case report. Am J Obstet Gynecol 2005; 193 (05) 1750-1752 . Doi: 10.1016/j.ajog.2005.08.021
    CrossrefPubMedGoogle Scholar
  • 8 Micheletti AM, Silva ACL, Nascimento AG, Da Silva CS, Murta EFC, Adad SJ. Cellular angiofibroma of the vulva: case report with clinicopathological and immunohistochemistry study. Sao Paulo Med J 2005; 123 (05) 250-252 . Doi: 10.1590/s1516-31802005000500010
    CrossrefPubMedGoogle Scholar
  • 9 Kumar P, Singh S, Kumar A, Janoria S. A rare case of cellular angiofibroma affecting the periurethral region in a 38-year-old woman. BMJ Case Rep 2018; 2018 . pii: bcr-2018–225386 DOI: 10.1136/bcr-2018-225386.
    CrossrefPubMedGoogle Scholar
  • 10 Santiago D, Perlman B, Lespinasse P, Chokshi R, Galan M, Heller DS. Massive cellular angiofibroma of the vulva. J Low Genit Tract Dis 2017; 21 (03) e28-e29 . Doi: 10.1097/LGT.0000000000000311
    CrossrefPubMedGoogle Scholar