Homœopathic Links 2020; 33(02): 090-098
DOI: 10.1055/s-0040-1712479
Original Article
Thieme Medical and Scientific Publishers Private Ltd.

Homoeopathic Management of Breast Fibroadenoma—An Open Label, Single Arm, Observational Trial

Purnima Shukla
1  Homoeopathic consultant, Holistic Medical Research Foundation, C-4, Shivalik, Malviya Nagar, New Delhi- 110 017
,
Purak Misra
2  Department of Surgery, ESIC Medical College, Faridabad, Haryana, India
,
Rajiv Kumar Misra
3  Department of Pathology, B.R.D Medical College, Gorakhpur, Uttar Pradesh, India
,
Rishabh Kumar Jain
4  Department of Radiodiagnosis, B.R.D Medical College, Gorakhpur, Uttar Pradesh, India
,
Rakesh Shukla
5  Department of Pharmacology, Central Drug Research Institute, Lucknow, Uttar Pradesh, India
,
R.K Manchanda
6  Central Council for Research in Homeopathy, New Delhi, India
,
Anil Khurana
6  Central Council for Research in Homeopathy, New Delhi, India
› Author Affiliations
Further Information

Publication History

Publication Date:
26 June 2020 (online)

Abstract

Background Fibroadenoma of breast is the commonest ailment of women with significant morbidity. Available literature revealed that breast tumour recedes by homoeopathic treatment.

The present study evaluated the role of homoeopathic treatment on breast fibroadenoma by using ‘Triple assessment criteria’ and to explore the mechanism, whether homoeopathic medicines bring their therapeutic effect by altering the oestrogen and progesterone receptor (ER/PR) status on tumour tissue.

Materials and Methods An open label, prospective, single arm, observational study was conducted on 64 female patients having fibroadenoma of breast. Triple assessment criteria were used to explore the effectiveness of homoeopathic treatment on breast fibroadenoma. Individualised homoeopathic medicines were prescribed. The outcome measures were changes in clinical picture, number and size of lump by ultrasonomammography. ER/PR study was performed by immunohistochemistry using quick score analysis.

Results Post-treatment response of 23 cases (35.93%) of fibroadenoma revealed disappearance of lump. Partial improvement was noticed in 22 cases (34.37%) with significant reduction in mean size (p < 0.001). Similarly significant reduction in number of lesions was seen in fibroadenoma (p <0.05). Conium maculatum and Phytolacca decandra were found to be the most useful remedies. Quick score value of ER after treatment showed significant reduction (Z = 4.910).

Conclusion The study revealed that the therapeutic effects of individualised homoeopathic medicines play significant role in management of fibroadenoma of breast. The results of ER/PR show significant reduction in ER suggesting that homoeopathic medicines have some inhibitory effect on ER.

Author Contribution

PS: Concept, literature search, clinical study, data acquisition, data interpretation and preparation of the article; PM: About the present modern medicine intervention, drafting the paper; RK Misra: Expert opinion regarding pathological investigation; RKJ: Ultrasonological examination and expert opinion; RS: Research advice; RK Manchanda and AK: Technical opinion regarding research. All the authors reviewed and approved the final paper.


Financial Support

The project was funded under the Extra-Mural Research Scheme of Ministry of Ayurveda, Yoga & Naturopathy, Unani, Siddha and Homoeopathy, Government of India (vide letter no F. No - 23 - 111/2009 - 10/CCRH/Tech/EMR/8758 dated 7th September 2009). Technical and administrative support was provided by the Central Council for Research in Homoeopathy.