Senologie - Zeitschrift für Mammadiagnostik und -therapie 2020; 17(02): e14-e15
DOI: 10.1055/s-0040-1710672
Abstracts
Senologie

Management of the axilla for high-risk early breast cancer (EBC) before and after neoadjuvant chemotherapy (NACT): an analysis of the multicentre GeparOcto trial

B Gerber
1  Department of Obstetrics and Gynaecology, University of Rostock, Rostock, Deutschland
,
A Schneeweiss
2  Nationales Centrum für Tumorerkrankungen, Heidelberg, Deutschland
,
V Möbus
3  University of Frankfurt, Frankfurt, Deutschland
,
M Golatta
4  Universitätsklinikum Heidelberg, Heidelberg, Deutschland
,
H Tesch
5  Bethanien Krankenhaus Frankfurt, Frankfurt, Deutschland
,
D Krug
6  Universitätsklinikum Schleswig-Holstein Kiel, Klinik für Strahlentherapie, Kiel, Deutschland
,
C Denkert
7  Universitätsklinikum Marburg, Institut für Pathologie UKGM, Marburg, Deutschland
,
K Lübbe
8  Diakovere Henriettenstiftung Hannover, Hannover, Deutschland
,
J Heil
4  Universitätsklinikum Heidelberg, Heidelberg, Deutschland
,
B Ataseven
9  Kliniken Essen Mitte, Essen, Deutschland
,
P Klare
10  Praxisklinik Krebsheilkunde für Frauen, Berlin, Deutschland
,
M Untch
11  HELIOS Clinic Berlin-Buch, Berlin, Deutschland
,
K Kast
12  Universitätsklinikum Carl Gustav Carus Dresden, Dresden, Deutschland
,
C Jackisch
13  Sana-Clinic Offenbach, Offenbach, Deutschland
,
F Seither
14  GBG, Neu-Isenburg, Deutschland
,
V Nekljudova
14  GBG, Neu-Isenburg, Deutschland
,
S Loibl
14  GBG, Neu-Isenburg, Deutschland
,
T Kühn
15  Klinikum Esslingen, Esslingen, Deutschland
› Author Affiliations
 

Background pCR in breast after NACT for patients with EBC correlates with initial lymph node status. We investigated the axilla management of patients with pN+ at presentation.

Methods Between 12/2014 and 06/2016, the neoadjuvant GeparOcto trial (Schneeweiss et al. EJC 2018) enrolled 961 patients. Sentinel lymph node biopsy (SLNB) in cN0 patients at baseline was not encouraged because of its impairing on pCR results.

Results At baseline 117/501 (23.4 %) of cN0 patients were diagnosed as pN1(sn) before NACT. 59/431 (13.7 %) cN+ patients were pN1(sn). In 233/431 (54.1 %) patients, cN+ was confirmed as pN+ by core biopsy as recommended. Overall, 443 were pN+ at baseline, 182 by SLNB (59 initially cN+, 117 initially cN0; 6 cN missing), 242 by biopsy, 19 by ALND. Of those 242 patients with pN+ confirmed by biopsy before NACT, 132 (54.5 %) were ycN0 after NACT (5.4 % received SLNB, 94.6 % ALND) and 77 (31.8 %) were ycN+ (9.1 % received SLNB, 90.9 % ALND), 33 had no examination. In addition to 95.6 % of patients with pN0 at baseline, 35.2 % of patients with pN+ at baseline diagnosed by SLNB did not undergo axillary surgery.

Conclusions SLNB at baseline was performed in cN0 and cN+ (which is not recommended) impairing pCR evaluation. 35 % of patients with pN+ by SLNB before NACT did not receive any further surgical procedure. All patients with pN+ by biopsy before NACT underwent axillary surgery as recommended. Axillary procedures in neoadjuvant treated patients are very variable and do not always adhere to guidelines.



Publication History

Publication Date:
24 June 2020 (online)

© Georg Thieme Verlag KG
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