Abstract
Chronic limb-threatening ischemia (CLTI) is a severe form of peripheral artery disease
associated with high rates of limb loss. The primary goal of treatment in CLTI is
limb salvage via revascularization. Multidisciplinary teams provide improved care
for those with CLTI and lead to improved limb salvage rates. Not all patients are
candidates for revascularization, and a subset will require major amputation. This
article highlights the role of amputations in the management of CLTI, and describes
the patients who should be offered primary amputation.
Keywords
amputation - peripheral artery disease - chronic limb-threatening ischemia - artery
- risk factors - end-stage renal disease