Chitin Analog AVR-25 Prevents Experimental Bronchopulmonary DysplasiaFunding This work was partly supported by a research contract grant received from AyuVis Research Inc.
13 February 2020
27 March 2020
08 May 2020 (online)
Infants born extremely preterm are at a high risk of developing bronchopulmonary dysplasia (BPD) which is characterized by large, simplified alveoli, increased inflammation, disrupted and dysregulated vasculogenesis, decreased cell proliferation, and increased cell death in the lungs. Due to lack of specific drug treatments to combat this condition, BPD and its long-term complications have taken a significant toll of healthcare resources. AVR-25, a novel immune modulator experimental compound, was able to partially recover the pulmonary phenotype in the hyperoxia-induced experimental mouse model of BPD. We anticipate that AVR-25 will have therapeutic potential for managing human BPD.
* Current affiliation: Cooper Health University and Hospital, Suite 206, 401 Haddon Avenue, Education and Research Building, Camden, NJ 08103, USA.
** These authors contributed equally to this article.
P.D., S.A., B.A., and V.B. conceptualized and designed the study, drafted the initial manuscript, and submitted as approved; P.D., S.A., D.S., B.A., and V.P. performed the initial experiments. All the authors approved the final manuscript.
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