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CC BY-NC-ND 4.0 · Eur J Dent 2020; 14(02): 294-298
DOI: 10.1055/s-0040-1709944
Original Article

Anti-Inflammatory Effect of Musa acuminata Stem

Maharani Laillyza Apriasari
1   Department of Oral Medicine, Faculty of Dentistry, Lambung Mangkurat University, Kalimantan Selatan, Indonesia
,
Selviana Rizky Pramitha
1   Department of Oral Medicine, Faculty of Dentistry, Lambung Mangkurat University, Kalimantan Selatan, Indonesia
,
Dewi Puspitasari
2   Department of Dental Material, Faculty of Dentistry, Lambung Mangkurat University, Kalimantan Selatan, Indonesia
,
Diah Savitri Ernawati
3   Department of Oral Medicine, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia
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Abstract

Objective This study was designed to assess the anti-inflammatory effect of Musa acuminata through the expression of tumor necrosis factor-α (TNF-α) and nuclear factor kappa β (NF-κB) after 3 days of application of Musa acuminata stem extract (MASE) gel on oral mucosal wound.

Materials and Methods An experimental study with post-test only control group design was conducted. Twenty male Rattus norvegicus (Wistar) were injured on their left buccal mucosa and treated three times a day with MASE gel of varying concentrations: 0% (as control), MASE 25%, MASE 37.5%, and MASE 50%. On day 3, a biopsy was performed on each mucosal wound for later immunohistochemical analysis for the expressions of TNF-α and NF-κB.

Results The highest expression of TNF-α was observed in the control group (13.20 ± 1.79), while the lowest was in the treatment group using 50% MASE (6.40 ± 1.14). Meanwhile the comparison between treatment groups did not highlight any significant difference (p > 0.05). The highest expression of NF-κB was observed in the control group (13.20 ± 1.30), whereas the lowest was in the treatment group using MASE 50% (6.40 ± 1.14). NF-κB was significantly lower in the treatment group using MASE 50% when compared with other treatment groups (p < 0.05).

Conclusion Application of MASE on mucosal wound reduces the expression of TNF-α and NF-κB at all concentrations. The anti-inflammatory effect of MASE 50% was the strongest one.

Keywords

Musa acuminata - anti-inflammation - TNF-α - NF-κB


Publication History

Article published online:
12 May 2020

© .

Thieme Medical and Scientific Publishers Private Ltd.
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