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CC BY 4.0 · Eur J Dent 2020; 14(02): 281-287
DOI: 10.1055/s-0040-1709924
Original Article

Effectiveness of Probiotic Lozenges in Periodontal Management of Chronic Periodontitis Patients: Clinical and Immunological Study

Ahmed Alshareef
1   Faculty of Dentistry, Umm Al-Qura University, Makkah, Saudi Arabia
,
Alaa Attia
1   Faculty of Dentistry, Umm Al-Qura University, Makkah, Saudi Arabia
2   Faculty of Dentistry, Al-Azhar University, Assiut, Egypt
,
Mohammed Almalki
1   Faculty of Dentistry, Umm Al-Qura University, Makkah, Saudi Arabia
,
Faisal Alsharif
1   Faculty of Dentistry, Umm Al-Qura University, Makkah, Saudi Arabia
,
Ahmed Melibari
1   Faculty of Dentistry, Umm Al-Qura University, Makkah, Saudi Arabia
,
Bassel Mirdad
1   Faculty of Dentistry, Umm Al-Qura University, Makkah, Saudi Arabia
,
Ehab Azab
1   Faculty of Dentistry, Umm Al-Qura University, Makkah, Saudi Arabia
,
Abdel-Rahman Youssef
1   Faculty of Dentistry, Umm Al-Qura University, Makkah, Saudi Arabia
3   Department of Microbiology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
,
Ahmed Dardir
1   Faculty of Dentistry, Umm Al-Qura University, Makkah, Saudi Arabia
4   Faculty of Dentistry, Al-Ahram Canadian University, Giza Governorate, Egypt
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Abstract

Objective The main purpose of this article was to evaluate the effect of probiotics used as an adjunctive to scaling and root planing (SRP) on the periodontal parameters and matrix metalloproteinase-8 (MMP-8) levels in gingival crevicular fluid (GCF) of chronic periodontitis patients.

Materials and Methods A total of 25 chronic periodontitis patients who completed the treatment course of 40 subjects, aged 25 to 58 years, participated in this study. They were categorized into two groups: the first group was treated by SRP while the second group was treated by SRP and probiotic lozenges twice a day for 30 days. All patients were evaluated clinically by measuring the plaque index, bleeding index (BI), pocket depth, clinical attachment loss, and immunologically by assaying GCF/MMP-8 at baseline and 30 days after periodontal management.

Results There was a significant improvement in periodontal parameters after SRP treatment with and without probiotic lozenges in both groups. However, there was a significant decrease in the BI (p = 0.05) in SRP and probiotic lozenges group after 30 days compared with SRP alone. In addition, there was a significant decrease in GCF/MMP-8 levels after 30 days in patients managed by SRP only (p = 0.017) compared with the baseline in both groups, whereas a highly significant decrease in patients treated by SRP and probiotics (p = 0.001).

Conclusion The current study suggested that the probiotics might have a beneficial effect on clinical and immunological outcomes in the management of chronic periodontitis patients. Further research is needed on a large-scale population and for a long recall time to confirm the response to probiotics as an adjunctive to SRP.

Keywords

probiotic lozenges - GCF/MMP-8 - chronic periodontitis - periodontal therapy


Publication History

Article published online:
21 May 2020

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