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CC BY-NC-ND 4.0 · Rev Bras Ortop (Sao Paulo) 2021; 56(04): 425-431
DOI: 10.1055/s-0040-1709732
DOI: 10.1055/s-0040-1709732
Artigo de Atualização
Oncologia
Tratamento medicamentoso da sarcopenia
Article in several languages: português | English
Resumo
A sarcopenia vem ganhando cada vez mais importância na literatura científica e nos consultórios médicos. Com o envelhecimento da população, essa condição clínica se torna cada vez mais imprescindível de se conhecer, se prevenir e de se tratar. O objetivo desta revisão é trazer as evidências atuais sobre o diagnóstico dessa patologia, de forma prática, bem como as principais opções atuais de tratamento.
Publication History
Received: 21 October 2019
Accepted: 27 January 2020
Publication Date:
22 September 2020 (online)
© 2020. Sociedade Brasileira de Ortopedia e Traumatologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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Referências
- 1 Rosenberg IH, Roubenoff R. Stalking sarcopenia. Ann Intern Med 1995; 123 (09) 727-728
- 2 Cesari M, Leeuwenburgh C, Lauretani F. et al. Frailty syndrome and skeletal muscle: results from the Invecchiare in Chianti study. Am J Clin Nutr 2006; 83 (05) 1142-1148
- 3 Riechman SE, Schoen RE, Weissfeld JL, Thaete FL, Kriska AM. Association of physical activity and visceral adipose tissue in older women and men. Obes Res 2002; 10 (10) 1065-1073
- 4 Ryan AS, Nicklas BJ. Age-related changes in fat deposition in mid-thigh muscle in women: relationships with metabolic cardiovascular disease risk factors. Int J Obes Relat Metab Disord 1999; 23 (02) 126-132
- 5 Stenholm S, Harris TB, Rantanen T, Visser M, Kritchevsky SB, Ferrucci L. Sarcopenic obesity: definition, cause and consequences. Curr Opin Clin Nutr Metab Care 2008; 11 (06) 693-700
- 6 Grimby G, Saltin B. The ageing muscle. Clin Physiol 1983; 3 (03) 209-218
- 7 Goodpaster BH, Park SW, Harris TB. et al. The loss of skeletal muscle strength, mass, and quality in older adults: the health, aging and body composition study. J Gerontol A Biol Sci Med Sci 2006; 61 (10) 1059-1064
- 8 Janssen I, Shepard DS, Katzmarzyk PT, Roubenoff R. The healthcare costs of sarcopenia in the United States. J Am Geriatr Soc 2004; 52 (01) 80-85
- 9 Abellan van Kan G. Epidemiology and consequences of sarcopenia. J Nutr Health Aging 2009; 13 (08) 708-712
- 10 Cruz-Jentoft AJ, Bahat G, Bauer J. et al. Writing Group for the European Working Group on Sarcopenia in Older People 2 (EWGSOP2), and the Extended Group for EWGSOP2. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing 2019; 48 (01) 16-31
- 11 Lira VA, Araújo C. Teste de sentar-levantar: estudos de fidedignidade. Rev Bras Ciên Mov 2000; 8 (02) 11-20
- 12 Gong Z, Muzumdar RH. Pancreatic function, type 2 diabetes, and metabolism in aging. Int J Endocrinol 2012; 2012: 320482
- 13 Srikanthan P, Karlamangla AS. Muscle mass index as a predictor of longevity in older adults. Am J Med 2014; 127 (06) 547-553
- 14 Schaap LA, van Schoor NM, Lips P, Visser M. Associations of Sarcopenia Definitions, and Their Components, With the Incidence of Recurrent Falling and Fractures: The Longitudinal Aging Study Amsterdam. J Gerontol A Biol Sci Med Sci 2018; 73 (09) 1199-1204
- 15 Janssen I. The epidemiology of sarcopenia. Clin Geriatr Med 2011; 27 (03) 355-363
- 16 Cawthon PM, Lui LY, Taylor BC. et al. Clinical Definitions of Sarcopenia and Risk of Hospitalization in Community-Dwelling Older Men: The Osteoporotic Fractures in Men Study. J Gerontol A Biol Sci Med Sci 2017; 72 (10) 1383-1389
- 17 Rennie MJ, Wackerhage H, Spangenburg EE, Booth FW. Control of the size of the human muscle mass. Annu Rev Physiol 2004; 66: 799-828
- 18 Cermak NM, Res PT, de Groot LC, Saris WH, van Loon LJ. Protein supplementation augments the adaptive response of skeletal muscle to resistance-type exercise training: a meta-analysis. Am J Clin Nutr 2012; 96 (06) 1454-1464
- 19 Moore DR, Churchward-Venne TA, Witard O. et al. Protein ingestion to stimulate myofibrillar protein synthesis requires greater relative protein intakes in healthy older versus younger men. J Gerontol A Biol Sci Med Sci 2015; 70 (01) 57-62
- 20 Kumar V, Selby A, Rankin D. et al. Age-related differences in the dose-response relationship of muscle protein synthesis to resistance exercise in young and old men. J Physiol 2009; 587 (01) 211-217
- 21 Barbosa-Silva TG, Menezes AM, Bielemann RM, Malmstrom TK, Gonzalez MC. Grupo de Estudos em Composição Corporal e Nutrição (COCONUT). Enhancing SARC-F: Improving Sarcopenia Screening in the Clinical Practice. J Am Med Dir Assoc 2016; 17 (12) 1136-1141
- 22 Roberts HC, Denison HJ, Martin HJ. et al. A review of the measurement of grip strength in clinical and epidemiological studies: towards a standardised approach. Age Ageing 2011; 40 (04) 423-429
- 23 Fess EE. Grip strength. In: Casanova JS. editor. Clinical assessment recommendations. 2nd ed. Chicago: American Society of Hand Therapists; 1992: 41-45
- 24 Morley JE. Sarcopenia: diagnosis and treatment. J Nutr Health Aging 2008; 12 (07) 452-456
- 25 Heymsfield SB, Smith R, Aulet M. et al. Appendicular skeletal muscle mass: measurement by dual-photon absorptiometry. Am J Clin Nutr 1990; 52 (02) 214-218
- 26 Horstman AM, Dillon EL, Urban RJ, Sheffield-Moore M. The role of androgens and estrogens on healthy aging and longevity. J Gerontol A Biol Sci Med Sci 2012; 67 (11) 1140-1152
- 27 Leenders M, Verdijk LB, van der Hoeven L, van Kranenburg J, Nilwik R, van Loon LJ. Elderly men and women benefit equally from prolonged resistance-type exercise training. J Gerontol A Biol Sci Med Sci 2013; 68 (07) 769-779
- 28 Mitchell CJ, Churchward-Venne TA, West DW. et al. Resistance exercise load does not determine training-mediated hypertrophic gains in young men. J Appl Physiol (1985) 2012; 113 (01) 71-77
- 29 Churchward-Venne TA, Burd NA, Mitchell CJ. et al. Supplementation of a suboptimal protein dose with leucine or essential amino acids: effects on myofibrillar protein synthesis at rest and following resistance exercise in men. J Physiol 2012; 590 (11) 2751-2765
- 30 Pennings B, Groen B, de Lange A. et al. Amino acid absorption and subsequent muscle protein accretion following graded intakes of whey protein in elderly men. Am J Physiol Endocrinol Metab 2012; 302 (08) E992-E999
- 31 Yang Y, Breen L, Burd NA. et al. Resistance exercise enhances myofibrillar protein synthesis with graded intakes of whey protein in older men. Br J Nutr 2012; 108 (10) 1780-1788
- 32 Witard OC, Jackman SR, Breen L, Smith K, Selby A, Tipton KD. Myofibrillar muscle protein synthesis rates subsequent to a meal in response to increasing doses of whey protein at rest and after resistance exercise. Am J Clin Nutr 2014; 99 (01) 86-95
- 33 Geirsdottir OG, Arnarson A, Ramel A, Jonsson PV, Thorsdottir I. Dietary protein intake is associated with lean body mass in community-dwelling older adults. Nutr Res 2013; 33 (08) 608-612
- 34 Tieland M, van de Rest O, Dirks ML. et al. Protein supplementation improves physical performance in frail elderly people: a randomized, double-blind, placebo-controlled trial. J Am Med Dir Assoc 2012; 13 (08) 720-726
- 35 Volpi E, Kobayashi H, Sheffield-Moore M, Mittendorfer B, Wolfe RR. Essential amino acids are primarily responsible for the amino acid stimulation of muscle protein anabolism in healthy elderly adults. Am J Clin Nutr 2003; 78 (02) 250-258
- 36 Anthony JC, Yoshizawa F, Anthony TG, Vary TC, Jefferson LS, Kimball SR. Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway. J Nutr 2000; 130 (10) 2413-2419
- 37 Sancak Y, Bar-Peled L, Zoncu R, Markhard AL, Nada S, Sabatini DM. Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell 2010; 141 (02) 290-303
- 38 Moore DR, Robinson MJ, Fry JL. et al. Ingested protein dose response of muscle and albumin protein synthesis after resistance exercise in young men. Am J Clin Nutr 2009; 89 (01) 161-168
- 39 Churchward-Venne TA, Breen L, Di Donato DM. et al. Leucine supplementation of a low-protein mixed macronutrient beverage enhances myofibrillar protein synthesis in young men: a double-blind, randomized trial. Am J Clin Nutr 2014; 99 (02) 276-286
- 40 Koopman R, Wagenmakers AJ, Manders RJ. et al. Combined ingestion of protein and free leucine with carbohydrate increases postexercise muscle protein synthesis in vivo in male subjects. Am J Physiol Endocrinol Metab 2005; 288 (04) E645-E653
- 41 Katsanos CS, Kobayashi H, Sheffield-Moore M, Aarsland A, Wolfe RR. A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly. Am J Physiol Endocrinol Metab 2006; 291 (02) E381-E387
- 42 Molfino A, Gioia G, Rossi Fanelli F, Muscaritoli M. Beta-hydroxy-beta-methylbutyrate supplementation in health and disease: a systematic review of randomized trials. Amino Acids 2013; 45 (06) 1273-1292
- 43 Cruz-Jentoft AJ, Landi F, Schneider SM. et al. Prevalence of and interventions for sarcopenia in ageing adults: a systematic review. Report of the International Sarcopenia Initiative (EWGSOP and IWGS). Age Ageing 2014; 43 (06) 748-759
- 44 Wilkinson DJ, Hossain T, Hill DS. et al. Effects of leucine and its metabolite β-hydroxy-β-methylbutyrate on human skeletal muscle protein metabolism. J Physiol 2013; 591 (11) 2911-2923
- 45 Deutz NE, Pereira SL, Hays NP. et al. Effect of β-hydroxy-β-methylbutyrate (HMB) on lean body mass during 10 days of bed rest in older adults. Clin Nutr 2013; 32 (05) 704-712
- 46 Wilson GJ, Wilson JM, Manninen AH. Effects of beta-hydroxy-beta-methylbutyrate (HMB) on exercise performance and body composition across varying levels of age, sex, and training experience: A review. Nutr Metab (Lond) 2008; 5: 1 DOI: 10.1186/1743-7075-5-1.
- 47 Stout JR, Sue Graves B, Cramer JT. et al. Effects of creatine supplementation on the onset of neuromuscular fatigue threshold and muscle strength in elderly men and women (64 - 86 years). J Nutr Health Aging 2007; 11 (06) 459-464
- 48 Baier S, Johannsen D, Abumrad N, Rathmacher JA, Nissen S, Flakoll P. Year-long changes in protein metabolism in elderly men and women supplemented with a nutrition cocktail of beta-hydroxy-beta-methylbutyrate (HMB), L-arginine, and L-lysine. JPEN J Parenter Enteral Nutr 2009; 33 (01) 71-82
- 49 Gotshalk LA, Kraemer WJ, Mendonca MA. et al. Creatine supplementation improves muscular performance in older women. Eur J Appl Physiol 2008; 102 (02) 223-231
- 50 Devries MC, Phillips SM. Creatine supplementation during resistance training in older adults-a meta-analysis. Med Sci Sports Exerc 2014; 46 (06) 1194-1203
- 51 Kersey RD, Elliot DL, Goldberg L. et al. National Athletic Trainers' Association. National Athletic Trainers' Association position statement: anabolic-androgenic steroids. J Athl Train 2012; 47 (05) 567-588
- 52 Silva TA, Frisoli Junior A, Pinheiro MM, Szenjfeld VL. Sarcopenia associada ao envelhecimento: aspectos etiológicos e opções terapêuticas. Rev Bras Reumatol 2006; 46 (06) 391-397
- 53 Vaisberg M, Mello MT. Exercícios na saúde e na doença. Barueri, São Paulo: Manole; 2010
- 54 Isidori AM, Giannetta E, Greco EA. et al. Effects of testosterone on body composition, bone metabolism and serum lipid profile in middle-aged men: a meta-analysis. Clin Endocrinol (Oxf) 2005; 63 (03) 280-293
- 55 Sinha-Hikim I, Cornford M, Gaytan H, Lee ML, Bhasin S. Effects of testosterone supplementation on skeletal muscle fiber hypertrophy and satellite cells in community-dwelling older men. J Clin Endocrinol Metab 2006; 91 (08) 3024-3033
- 56 Vigen R, O'Donnell CI, Barón AE. et al. Association of testosterone therapy with mortality, myocardial infarction, and stroke in men with low testosterone levels. JAMA 2013; 310 (17) 1829-1836
- 57 Heufelder AE, Saad F, Bunck MC, Gooren L. Fifty-two-week treatment with diet and exercise plus transdermal testosterone reverses the metabolic syndrome and improves glycemic control in men with newly diagnosed type 2 diabetes and subnormal plasma testosterone. J Androl 2009; 30 (06) 726-733
- 58 Kanayama G, Brower KJ, Wood RI, Hudson JI, Pope Jr HG. Anabolic-androgenic steroid dependence: an emerging disorder. Addiction 2009; 104 (12) 1966-1978