Radiation-Induced Cervical Spinal Cord Cavernoma Following Head and Neck Radiotherapy: Case Report

Abstract

Cavernous angiomas are congenital vascular malformations that affect the central nervous system. Reports implicated radiation therapy as a triggering factor for the formation of cavernomas but not in relation with head and neck radiation therapy. Radiation-induced cavernomas (RIC) should be considered in the differential diagnosis of focal neurological symptoms in any patient who has received previous cranial-spinal or head and neck radiotherapy.

Keywords

arteriovenous malformation - head and neck cancer - radiation induced cavernoma - spinal cord cavernous angiomas

• References

• 1 Koike T, Yanagimachi N, Ishiguro H. , et al. High incidence of radiation-induced cavernous hemangioma in long-term survivors who underwent hematopoietic stem cell transplantation with radiation therapy during childhood or adolescence. Biol Blood Marrow Transplant 2012; 18 (07) 1090-1098
• 2 Flemming KD, Link MJ, Christianson TJ, Brown Jr RD. Prospective hemorrhage risk of intracerebral cavernous malformations. Neurology 2012; 78 (09) 632-636
• 3 Nimjee SM, Powers CJ, Bulsara KR. Review of the literature on de novo formation of cavernous malformations of the central nervous system after radiation therapy. Neurosurg Focus 2006; 21 (01) e4
• 4 Heckl S, Aschoff A, Kunze S. Radiation-induced cavernous hemangiomas of the brain: a late effect predominantly in children. Cancer 2002; 94 (12) 3285-3291