J Am Acad Audiol 2020; 31(08): 559-565
DOI: 10.1055/s-0040-1709517
Research Article

Auditory Gating in Hearing Loss

Julia Campbell
1   Department of Communication Sciences and Disorders, University of Texas at Austin, Austin, Texas
2   Central Sensory Processes Laboratory, University of Texas at Austin, Austin, Texas
,
Mashhood Nielsen
1   Department of Communication Sciences and Disorders, University of Texas at Austin, Austin, Texas
2   Central Sensory Processes Laboratory, University of Texas at Austin, Austin, Texas
,
Connor Bean
1   Department of Communication Sciences and Disorders, University of Texas at Austin, Austin, Texas
2   Central Sensory Processes Laboratory, University of Texas at Austin, Austin, Texas
,
Alison LaBrec
1   Department of Communication Sciences and Disorders, University of Texas at Austin, Austin, Texas
2   Central Sensory Processes Laboratory, University of Texas at Austin, Austin, Texas
› Institutsangaben
Funding This work was supported by the Hearing Health Foundation Emerging Research Grant, through support from Les Paul Foundation (2016), and the Texas Speech–Language–Hearing Foundation Lear Ashmore Research Fund (2016).

Abstract

Background Sensory gating is a measure used to evaluate inhibitory deficits underlying neurological disorders. However, the effects of hearing loss (HL), thought to decrease inhibition, remain unknown on gating function.

Purpose The goal of this study was to investigate gating performance in HL.

Research Design This was a prospective, cross-sectional study with independent group comparison and correlational design.

Study Sample Eleven adults (mean age/standard deviation = 47.546 ± 7.967 years) with normal hearing (NH) and 11 adults (mean age/standard deviation = 56.273 ± 13.871 years) with mild–moderate high-frequency HL.

Data Collection and Analysis Cortical auditory evoked potentials (CAEPs) were recorded in response to tonal pairs via high-density electroencephalography. The CAEP response to the second tone in the pair (S2) was compared with the response to the first tone in the pair (S1) within groups. Amplitude gating indices were compared between groups and correlated with auditory behavioral measures. Current density reconstructions were performed to estimate cortical gating generators.

Results Amplitude gating indices were decreased and correlated with elevated auditory thresholds. Gating generators in temporal, frontal, and prefrontal regions were localized in the NH group, while HL gating was localized in mainly temporal and parietal areas.

Conclusions Reduced inhibition may be associated with compensatory cortical gating networks in HL and should be considered when utilizing gating in clinical populations.



Publikationsverlauf

Eingereicht: 23. Juli 2019

Angenommen: 30. Dezember 2019

Artikel online veröffentlicht:
27. April 2020

© 2020. American Academy of Audiology. This article is published by Thieme.

Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA

 
  • References

  • 1 Hamilton HK, Williams TJ, Ventura J. et al. Clinical and cognitive significance of auditory sensory processing deficits in schizophrenia. Am J Psychiatry 2018; 175 (03) 275-283
  • 2 Campbell J, Bean C, LaBrec A. Normal hearing young adults with mild tinnitus: reduced inhibition as measured through sensory gating. Audiology Res 2018; 8 (02) 214
  • 3 Campbell J, LaBrec A, Bean C, Nielsen M, So W. Auditory gating and extended high-frequency thresholds in normal-hearing adults with minimal tinnitus. Am J Audiol 2019; 28 (1S(: 209-224
  • 4 Chien YL, Hsieh MH, Gau SS. P50-N100-P200 sensory gating deficits in adolescents and young adults with autism spectrum disorders. Prog Neuropsychopharmacol Biol Psychiatry 2019; 95: 109683
  • 5 Javitt DC, Freedman R. Sensory processing dysfunction in the personal experience and neuronal machinery of schizophrenia. Am J Psychiatry 2015; 172 (01) 17-31
  • 6 Knott V, Millar A, Fisher D. Sensory gating and source analysis of the auditory P50 in low and high suppressors. Neuroimage 2009; 44 (03) 992-1000
  • 7 Knott VJ, Fisher DJ, Millar AM. Differential effects of nicotine on P50 amplitude, its gating, and their neural sources in low and high suppressors. Neuroscience 2010; 170 (03) 816-826
  • 8 Vlcek P, Bob P, Raboch J. Sensory disturbances, inhibitory deficits, and the P50 wave in schizophrenia. Neuropsychiatr Dis Treat 2014; 10: 1309-1315
  • 9 Fuerst DR, Gallinat J, Boutros NN. Range of sensory gating values and test-retest reliability in normal subjects. Psychophysiology 2007; 44 (04) 620-626
  • 10 Noreña AJ, Farley BJ. Tinnitus-related neural activity: theories of generation, propagation, and centralization. Hear Res 2013; 295: 161-171
  • 11 Eggermont JJ. Acquired hearing loss and brain plasticity. Hear Res 2017; 343: 176-190
  • 12 Recanzone G. The effects of aging on auditory cortical function. Hear Res 2018; 366: 99-105
  • 13 Harkrider AW, Plyler PN, Hedrick MS. Effects of age and spectral shaping on perception and neural representation of stop consonant stimuli. Clin Neurophysiol 2005; 116 (09) 2153-2164
  • 14 Bertoli S, Probst R, Bodmer D. Late auditory evoked potentials in elderly long-term hearing-aid users with unilateral or bilateral fittings. Hear Res 2011; 280 (1–2): 58-69
  • 15 Campbell J, Sharma A. Compensatory changes in cortical resource allocation in adults with hearing loss. Front Syst Neurosci 2013; 7: 71
  • 16 Bertoli S, Bodmer D. Novel sounds as a psychophysiological measure of listening effort in older listeners with and without hearing loss. Clin Neurophysiol 2014; 125 (05) 1030-1041
  • 17 Parry LV, Maslin MRD, Schaette R, Moore DR, Munro KJ. Increased auditory cortex neural response amplitude in adults with chronic unilateral conductive hearing impairment. Hear Res 2019; 372: 10-16
  • 18 Smith DM, Grant B, Fisher DJ, Borracci G, Labelle A, Knott VJ. Auditory verbal hallucinations in schizophrenia correlate with P50 gating. Clin Neurophysiol 2013; 124 (07) 1329-1335
  • 19 Newman CW, Jacobson GP, Spitzer JB. Development of the Tinnitus Handicap Inventory. Arch Otolaryngol Head Neck Surg 1996; 122 (02) 143-148
  • 20 Delorme A, Makeig S. EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. J Neurosci Methods 2004; 134 (01) 9-21
  • 21 Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Series B Stat Methodol 1995; 57: 289-300
  • 22 Makeig S, Jung TP, Bell AJ, Ghahremani D, Sejnowski TJ. Blind separation of auditory event-related brain responses into independent components. Proc Natl Acad Sci U S A 1997; 94 (20) 10979-10984
  • 23 Pascual-Marqui RD. Standardized low-resolution brain electromagnetic tomography (sLORETA): technical details. Methods Find Exp Clin Pharmacol 2002; 24 (Suppl D): 5-12
  • 24 Fuchs M, Kastner J, Wagner M, Hawes S, Ebersole JS. A standardized boundary element method volume conductor model. Clin Neurophysiol 2002; 113 (05) 702-712
  • 25 Cheng CH, Baillet S, Lin YY. Region-specific reduction of auditory sensory gating in older adults. Brain Cogn 2015; 101: 64-72
  • 26 Lamminmäki S, Parkkonen L, Hari R. Human neuromagnetic steady-state responses to amplitude-modulated tones, speech, and music. Ear Hear 2014; 35 (04) 461-467
  • 27 Mayer AR, Hanlon FM, Franco AR. et al. The neural networks underlying auditory sensory gating. Neuroimage 2009; 44 (01) 182-189
  • 28 Josef Golubic S, Aine CJ, Stephen JM, Adair JC, Knoefel JE, Supek S. MEG biomarker of Alzheimer's disease: absence of a prefrontal generator during auditory sensory gating. Hum Brain Mapp 2017; 38 (10) 5180-5194
  • 29 Rihs TA, Tomescu MI, Britz J. et al. Altered auditory processing in frontal and left temporal cortex in 22q11.2 deletion syndrome: a group at high genetic risk for schizophrenia. Psychiatry Res 2013; 212 (02) 141-149
  • 30 McClannahan KS, Backer KC, Tremblay KL. Auditory evoked responses in older adults with normal hearing, untreated, and treated age-related hearing loss. Ear Hear 2019; 40 (05) 1106-1116
  • 31 Lightfoot G. Summary of the N1–P2 cortical auditory evoked potential to estimate the auditory threshold in adults. Semin Hear 2016; 37 (01) 1-8
  • 32 Lijffijt M, Moeller FG, Boutros NN. et al. Diminished P50, N100 and P200 auditory sensory gating in bipolar I disorder. Psychiatry Res 2009; 167 (03) 191-201