Subscribe to RSS
Effect of Vitiligo on Auditory Functions: Is There Any Association?
Introduction Vitiligo is an acquired pigmentary disorder of unknown etiology, clinically characterized by whitish macules caused by selective loss of melanocytes. There are many melanocytes in the human cochlea. Recent studies have suggested a direct relation between cochlear dysfunction and decreased amounts of melanin.
Objective To determine the effect of vitiligo on auditory function.
Methods The present prospective, case control study was performed over a period of 1 year in patients between 15 and 40 years old with nonsegmental disease and the same number of controls. Pure tone audiometry (PTA) and Otoacoustic emission (OAE) were performed to analyze the correlation between vitiligo and auditory function.
Results The mean pure tone audiometric threshold in the right ear at 0.5, 8 kHz, and in the left ear at the frequency of 8 kHz in the case group were significantly higher as compared with controls. The average band reproducibility (%) in the right and left ear of controls was significantly higher at the frequency of 4 kHz as compared with cases. It has been observed that signal to noise ratio was statistically higher at the frequency of 5kHz in the right ear and at 2, 3, and 5kHz in the left ear in controls as compared with cases. On the basis of disease type and duration of disease; mean pure tone audiometric threshold, average band reproducibility and signal to noise ratio, no significant effect was observed in the present study.
Conclusion Vitiligo has an effect on cochlear function irrespective of the duration or distribution of the disease.
Received: 30 May 2019
Accepted: 25 February 2020
23 June 2020 (online)
© 2020. Fundação Otorrinolaringologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
Thieme Revinter Publicações Ltda.
Rua do Matoso 170, Rio de Janeiro, RJ, CEP 20270-135, Brazil
- 1 Lerner AB. On the etiology of vitiligo and gray hair. Am J Med 1971; 51 (02) 141-147
- 2 Howitz J, Brodthagen H, Schwartz M, Thomsen K. Prevalence of vitiligo. Epidemiological survey on the Isle of Bornholm, Denmark. Arch Dermatol 1977; 113 (01) 47-52
- 3 Woolfson H, Finn OA, Mackie RM, McQueen A, MacSween RNM. Serum anti-tumour antibodies and auto-antibodies in vitiligo. Br J Dermatol 1975; 92 (04) 395-400
- 4 Birbeck MS, Breathnach AS, Everall JD. An electron microscope study of Basal Melanocytes and High-Level Clear Cells (Langerhans Cells) in Vitiligo. J Invest Dermatol 1961; 37: 51-64
- 5 Gawkrodger DJ, Ormerod AD, Shaw L. et al; Therapy Guidelines and Audit Subcommittee, British Association of Dermatologists, Clinical Standards Department, Royal College of Physicians of London, Cochrane Skin Group, Vitiligo Society. Guideline for the diagnosis and management of vitiligo. Br J Dermatol 2008; 159 (05) 1051-1076
- 6 Alikhan A, Felsten LM, Daly M, Petronic-Rosic V. Vitiligo: a comprehensive overview Part I. Introduction, epidemiology, quality of life, diagnosis, differential diagnosis, associations, histopathology, etiology, and work-up. J Am Acad Dermatol 2011; 65 (03) 473-491
- 7 Savin C. The blood vessels and pigmentary cells of the inner ear. Ann Otol Rhinol Laryngol 1965; 74 (03) 611-622
- 8 Tosti A, Bardazzi F, Tosti G, Monti L. Audiologic abnormalities in cases of vitiligo. J Am Acad Dermatol 1987; 17 (2 Pt 1): 230-233
- 9 Shalaby MES, El-Zarea GA, Nassar AI. Auditory function in vitiligo patients. Egypt Dermatol Online J 2006; 2 (01) 1
- 10 Escalante-Ugalde C, Poblano A, Montes de Oca E, Lagunes R, Saúl A. No evidence of hearing loss in patients with vitiligo. Arch Dermatol 1991; 127 (08) 1240
- 11 Angrisani RM, Azevedo MF, Pereira LD, Lopes C, Garcia MV. A study on otoacoustic emissions and supression effects in patients with vitiligo. Rev Bras Otorrinolaringol (Engl Ed) 2009; 75 (01) 111-115
- 12 Mahdi P, Rouzbahani M, Amali A, Rezaii Khiabanlu S, Kamali M. Audiological manifestations in vitiligo patients. Iran J Otorhinolaryngol 2012; 24 (66) 35-40
- 13 Sharma L, Bhawan R, Jain RK. Hypoacusis in vitiligo. Indian J Dermatol Venereol Leprol 2004; 70 (03) 162-164
- 14 Elsaied MA, Naga YAA, Abdo IM. Evaluation of brain stem evoked response in vitiligo patients. J Pan-Arab League Dermatol. 2008; 19: 91-97