Journal of Pediatric Epilepsy 2020; 09(02): 031-035
DOI: 10.1055/s-0040-1709187
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Time Interval between First and Last Epileptic Seizures and Electroencephalogram Normalization in Benign Childhood Epilepsy with Centrotemporal Spikes: Influencing Factors

1  Department of Neurology, Faculdade de Medicina Hospital das Clinicas, Universidade de Sao Paulo, São Paulo, Brazil
,
2  Department of Bioethics, Faculdade de Medicina do ABC, São Paulo, Brazil
,
Virginia Aparecida Gelmeti Serrano
3  Clinical Hospital of the University of São Paulo, São Paulo, Brazil
,
Denise Harumi Nakanishi
3  Clinical Hospital of the University of São Paulo, São Paulo, Brazil
,
5  Department of Bioethics, Universidade Nove de Julho, São Paulo, Brazil
,
3  Clinical Hospital of the University of São Paulo, São Paulo, Brazil
,
3  Clinical Hospital of the University of São Paulo, São Paulo, Brazil
› Author Affiliations
Further Information

Publication History

13 December 2019

04 March 2020

Publication Date:
15 April 2020 (online)

Abstract

The aim of this study was to evaluate the interval between the first and last seizures, the normalization of the electroencephalogram (EEG), and to identify factors of influence. Medical records of children were analyzed with benign childhood epilepsy with centrotemporal spikes. Variables age at first and last seizure, gender, interval between the first and last seizure, the first seizure and EEG normalization, lateralization of the epileptiform discharges, and last epileptic seizure and EEG normalization. The mean time between the first and last seizure was 3.34 years. Early onset of seizures and unilateral discharges were factors that increased the interval between the first and last seizures (p < 0.001). Interval between the last seizure and EEG normalization was 2.40 years, without influence of age (p = 0.986). Interval was shorter in bilateral discharges (p = 0.035). The antiepileptic medicine did not alter the natural history of disease progression. In younger children, the interval between last seizure and normalization of the EEG is reduced compared to older children.