CC BY-NC-ND 4.0 · Journal of Health and Allied Sciences NU 2018; 08(04): 034-039
DOI: 10.1055/s-0040-1708772
Review Article

Dysbiosis of Oral Microflora: A Review

Mithra N Hegde
1   Head of the Department, Department of Conservative Dentistry and Endodontics, A B Shetty Memorial institute of Dental Sciences, Nitte deemed to be university, Mangaluru, Karnataka, India
,
Mrinalini › Author Affiliations

Abstract

Microorganisms being an integral part of human body colonise various sites, with oral cavity being one of the most densely populated environment. Within the oral cavity there are varying environment, properties of which determines the type of microbes colonising the site, while the metabolic activities of these microorganisms later on modifies the environmental properties. These microorganisms when in equilibrium confer health benefit however any alteration in the flora allows the pathogenic bacteria to outgrow in numbers and cause oral disease. Such alteration could be due to various factors. The present review article focuses on the various aspects of oral microbial flora, their role in the body, dysbiosis and factors influencing along with the reestablishment of normal healthy microbiome. A search was made on pubmed and scopus using keywords and 25 relevant articles published during 2000 to 2018 along with their references were included in the study.

With increasing knowledge of human microbiome, attempts are made to limit the alteration in oral ecosystem or re-establish the normal healthy flora as a part of prevention or treatment of diseases. This brings about change in approach which initially focused on elimination of microbes to maintaining their equilibrium.



Publication History

Received: 15 October 2018

Accepted: 23 November 2018

Article published online:
21 April 2020

© .

Thieme Medical and Scientific Publishers Private Ltd.
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  • References

  • 1 Parahitiyawa NB, et al. Exploring the oral bacterial flora: current status and future directions. Oral Diseases 2010;16:136-145.
  • 2 The NIH Human Microbiome Project. Microbe Magazine. 2009;4(9):393-393.
  • 3 Sonnenburg J, Fischbach M. Community Health Care: Therapeutic Opportunities in the Human Microbiome. Science Translational Medicine. 2011;3(78):78ps12-78ps12.
  • 4 Takahashi N. Microbial ecosystem in the oral cavity: Metabolic diversity in an ecological niche and its relationship with oral diseases. International Congress Series 2005;1284:103-112.
  • 5 Aas J, Paster B, Stokes L, Olsen I, Dewhirst F. Defining the Normal Bacterial Flora of the Oral Cavity. Journal of Clinical Microbiology. 2005;43(11):5721-5732.
  • 6 Marsh PD. Role of the oral microflora in health. Microbial Ecology in Health and Disease 2000;12:130-137.
  • 7 Li M, Wang B, Zhang M, Rantalainen M, Wang S, Zhou H, Zhang Y, Shen J, Pang. Symbiotic gut microbes modulate human metabolic phenotypes. Proc Natl Acad Sci U S A 2008 Feb 12;105(6):2117-2122.
  • 8 Chen T, Yu WH, Izard J, Baranova OV, Lakshmanan A, Dewhirst FE. The human oral microbiome database: a web accessible resource for investigating oral microbe taxonomic and genomic information. Database (Oxford) 2010 Jul 6;2010:baq013.
  • 9 Ling Z, Kong J, Jia P, Wei C, Wang Y, Pan Z et al. Analysis of Oral Microbiota in Children with Dental Caries by PCR-DGGE and Barcoded Pyrosequencing. Microbial Ecology. 2010;60(3):677-690.
  • 10 Sleator R. The human superorganism- Of microbes and men. Medical Hypotheses. 2010;74(2):214-215
  • 11 Adler CJ, Dobney K, Weyrich LS, Kaidonis J, Walker AW, Haak W, Bradshaw CJ, Townsend G, Soltysiak A, Alt KW, et al. Sequencing ancient calcified dental plaque shows changes in oral microbiota with dietary shifts of the Neolithic and industrial revolutions. Nat Genet 2013 Apr;45(4):450-455, 455e1.
  • 12 Smith DJ, Anderson JM, King WF, van Houte J, Taubman MA. Oral streptococcal colonization of infants. Oral Micro-biol Immunol 1993; 8: 1–4.
  • 13 Pearce C, Bowden GH, Evans M, Fitsimmons SP, Johnson J, Sheridan MJ, et al. Identification of pioneer viridans streptococci in the oral cavity of human neonates. J Med Microbiol 1995; 42: 67–72
  • 14 Marsh PD. Role of the oral microflora in health. Microbial Ecology in Health and Disease. 2000 Jan 1;12(3):130-7.
  • 15 Batabyal B, Chakraborty S, Biswas S. Role of the oral micro flora in human population: A brief review. International Journal of Pharmacy & Life Sciences. 2012 Dec 1;3(12).
  • 16 Dagli N, Dagli R, Darwish S, Baroudi K. Oral microbial shift: factors affecting the microbiome and prevention of oral disease. J Contemp Dent Pract. 2016 Jan 1;17(1):90-6.
  • 17 Marsh PD. Contemporary perspective on plaque control. Br Dent J 2012 Jun 22;212(12):601-606.
  • 18 Marsh PD, Head DA, Devine DA. Ecological approaches to oral biofilms: control without killing. Caries Res 2015;49 (Suppl 1):46-54.
  • 19 Chaudhary M and Payasi A. Battling the Methicillin-Resistant Staphylococcus aureus Biofilm Challenge with Vancoplus. J Microbial Biochem Technol. 2014;S10-001.
  • 20 Bueno J. Anti-Biofilm Drug Susceptibility Testing Methods: Looking for New Strategies against Resistance Mechanism. J Microbial Biochem Technol. 2014;S3-004.
  • 21 Baier RE, et al. Suppressing Biodiversity in the World's Waterbodies: Ballast Biofilms are the Dental Plaque of the Oceans. J Biodivers Biopros Dev. 2014;1:109.
  • 22 Rajendhran J, Gunasekaran P. Human microbiomics. Indian Journal of Microbiology. 2010;50(1):109-112.
  • 23 Rajendhran J, Gunasekaran P (2010). Human microbiomics. Indian J Microbiol 50: 109–112.
  • 24 Gill SR, Pop M, Deboy RT, Eckburg PB, Turnbaugh PJ, Samuel BS, Gordon JI, Relman DA, Fraser-Liggett CM, Nelson KE. Metagenomic analysis of the human distal gut microbiome. Science 2006 Jun 2;312(5778): 1355-1359.
  • 25 Helmerhorst EJ, Zamakhchari M, Schuppan D, Oppenheim FG. Discovery of a novel and rich source of gluten-degrading microbial enzymes in the oral cavity. PLoS One 2010 Oct 11;5(10):e13264.
  • 26 Rosier BT, De Jager M, Zaura E, Krom BP. Historical and contemporary hypotheses on the development of oral diseases: are we there yet?. Frontiers in cellular and infection microbiology. 2014 Jul16;4:92.
  • 27 Patil S, Rao RS, Sanketh DS, Amrutha N. Microbialflora in oral diseases. The journal of contemporary dental practice. 2013 Nov 1;14(6):1202.
  • 28 Takahashi N. Microbial ecosystem in the oral cavity: Metabolic diversity in an ecological niche and its relationship with oral diseases. International Congress Series 2005;1284:103-112.
  • 29 Marsh PD. Dental plaque as a biofilm and a microbial community– implications for health and disease. BMC Oral Health 2006;6(14):1-7.
  • 30 Henry AG, Brooks AS, Piperno DR. Microfossils in calculus demonstrate consumption of plants and cooked foods in Neanderthal diets (Shanidar III, Iraq; Spy I and II, Belgium). Proc Natl Acad Sci U S A 2011 Jan 11;108(2):486-491.
  • 31 Warinner C, Rodrigues JF, Vyas R, Trachsel C, Shved N, Grossmann J, Radini A, Hancock Y, Tito RY, Fiddyments S, et al. Pathogens and host immunity in the ancient human oral cavity. Nat Genet 2014 Apr;46(4):336-344.
  • 32 Adler CJ, Dobney K, Weyrich LS, Kaidonis J, Walker AW, Haak W, Bradshaw CJ, Townsend G, Soltysiak A, Alt KW, et al. Sequencing ancient calcified dental plaque shows changes in oral microbiota with dietary shifts of the Neolithicand industrial revolutions. Nat Genet 2013 Apr;45(4):450-455,455e1.
  • 33 Ali SM, Tanwir F. Oral microbial habitat a dynamic entity. Journal of oral biology and craniofacial research. 2012 Sep 1;2(3):181-7
  • 34 Morhart RE, Fitzgerald RJ. Nutritional determinants of the ecology of the oral flora. Dental Clinics of North America. 1976 Jul;20(3):473-89.
  • 35 Gur T, Worly B, Bailey M. Stress and the Commensal Microbiota: Importance in Parturition and Infant Neurodevelopment. Frontiers in Psychiatry. 2015;6.
  • 36 Jentsch H, März D, Krüger M. The effects of stress hormones on growth of selected periodontitis related bacteria. Anaerobe. 2013;24:49-54.
  • 37 Roberts A, Matthews J, Socransky S, Freestone P, Williams P, Chapple I. Stress and the periodontal diseases: effects of catecholamines on the growth of periodontal bacteria in vitro. Oral Microbiology and Immunology. 2002;17(5):296-303.
  • 38 Rai B, Kaur J, Anand S, Jacobs R. Salivary Stress Markers, Stress, and Periodontitis: A Pilot Study. Journal of Periodontology. 2011;82(2):287-292.
  • 39 Duran-Pinedo AE, Solbiati J, Frias-Lopez J. The effect of the stress hormone cortisol on the metatranscriptome of the oral microbiome. npj Biofilms and Microbiomes. 2018 Oct 18;4(1):25.
  • 40 Jakobsson HE, Jernberg C, Andersson AF, Sjölund-Karlsson M, Jansson JK, Engstrand L. Short-term antibiotic treatment has differing longterm impacts on the human throat and gut microbiome. PLoS One 2010 Mar 24;5(3):e9836.
  • 41 Naeem Z. Health risks associated with mobile phones use. International journal of health sciences. 2014 Oct;8(4).
  • 42 Goldwein O, Aframian DJ. The influence of handheld mobile phones on human parotid gland secretion. Oral Dis 2010 Mar;16(2):146-150.
  • 43 Hamzany Y, Feinmesser R, Shpitzer T, Mizrachi A, Hilly O, Hod R, Bahar G, Otradnov I, Gavish M, Nagler RM. Is human saliva an indicator of the adverse health effects of using mobile phones? Antioxid Redox Signal 2013 Feb 20;18(6):622-627.
  • 44 MacFarlane TW, Mason DK. Changes in the oral flora in Sjögren's syndrome. Journal of clinical pathology. 1974 May 1;27(5):416-9.
  • 45 Hou J, Zheng H, Li P, Liu H, Zhou H, Yang X. Distinct shifts in the oral microbiota are associated with the progression and aggravation of mucositis during radiotherapy. Radiotherapy and Oncology. 2018 May 4.
  • 46 Brook I. The impact of smoking on oral and nasopharyngeal bacterial flora. Journal of dental research. 2011 Jun;90(6):704-10.
  • 47 Thomas AM, Gleber-Netto FO, Fernandes GR, Amorim M, Barbosa LF, Francisco AL, de Andrade AG, Setubal JC, Kowalski LP, Nunes DN, Dias- Neto E. Alcohol and tobacco consumption affects bacterial richness in oral cavity mucosa biofilms. BMC microbiology. 2014 Dec;14(1):250.
  • 48 Pandya D. Benefits of Probiotics in Oral cavity- Detailed Review. Ann Int Med dent Res. 2016;2(5):10-7.
  • 49 Bowen DM. Probiotics and oral health. American Dental Hygienists Association. 2013 Feb 1;87(1):5-9