Subscribe to RSS
DOI: 10.1055/s-0040-1708770
Applications of Photodynamic Therapy in Management of Periodontal Disease - A Review
Abstract
A novel noninvasive photochemical approach for infection control, namely photodynamic therapy, has received much attention in the treatment of oral diseases which requires three nontoxic ingredients namely visible harmless light, a photosensitizer and oxygen are involved in this therapy. It is based on the principle that a photosensitizer binds to the target cells which when activated by light of a suitable wavelength results in the production of singlet oxygen and other very reactive agents that are extremely toxic to certain cells and bacteria. This article highlights the application of photo-dynamic therapy in management of periodontal disease and its current status.
Publication History
Received: 05 November 2015
Accepted: 18 November 2018
Article published online:
21 April 2020
© .
Thieme Medical and Scientific Publishers Private Ltd.
A-12, Second Floor, Sector -2, NOIDA -201301, India
-
References
- 1 Takasaki AS, Aoki AI, Mizutani KJ et al. Application of Antimicrobial Photodynamic Therapy in Periodontal and Peri-Implant Diseases. Periodontol 2000 .2009; 51:109–140.
- 2 Rajesh S, Koshi E, Philip K, Mohan A.Antimicrobial photodynamic therapy: An overview. J Indian SocPeriodontol. 2011;15:323–7.
- 3 Dobson J, Wilson M. Sensitization of oral bacteria in biofilms to killing by light from a low-power laser. ArchOralBiol 1992;37:883-887.
- 4 Komerik N, Nakanishi H, MacRobert AJ. In vivo killing of Porphyromonasgingivalis by toluidine blue-mediated photosensitization in an animal model.Antimicrob Agents Chemother 2003;47:932-940.
- 5 Matevski D, Weersink R, Tenenbaum HC. Lethal photosensitization of periodontal pathogens by a red-filtered Xenon lamp in vitro. J Periodontal Res 2003;38:428-435.
- 6 Aoki A, Sasaki KM, Watanabe H, Ishikawa I.Lasers in nonsurgical periodontal therapy.Periodontol 2000.2004:36: 59–97.
- 7 Nagpal S, Dodwad V, Vaish S. Photodynamic therapy:-A novel approach towards dentistry.Journal of Pharmaceutical and Biomedical Sciences.21 ;( 14):1-4.
- 8 Fontana C.R., Abernethy A.D., Som S., Ruggiero K., Doucette S.,Marcantonio R.C.: The antibacterial effect of photodynamic therapy in dental plaque-derived biofilms. J. Periodont. Res., 2009; 44: 751- 759.
- 9 O'Neill J.F., Hope C.K., Wilson M.: Oral bacteria in multi-speciesbiofilms can be killed by red light in the presence of toluidine blue.Lasers Surg. Med., 2002; 31: 86-9.
- 10 Sterer N., Feuerstein O.: Effect of visible light on malodour production by mixed oral microflora. J. Med. Microbiol., 2005; 54: 1225-1229.
- 11 Sorkhdini P., Moslemi N., Jamshidi S: Effect of hydrosoluble chlorinemediated antimicrobial photodynamic therapy on clinical parameters and cytokine profile in ligature-induced periodontitis in dogs. J. Periodontol.,2013; 84: 793-800.
- 12 Arweiler NB, Pietruska M, Pietruski J, et al. Six-month results following treatment of aggressive periodontitis with antimicrobial photodynamic therapy or amoxicillin and metronidazole. Clin Oral Investig 2014;18(9):2129–35.
- 13 Arweiler NB, Pietruska M, Skurska A, et al. Nonsurgical treatment of aggressive periodontitis with photodynamic therapy or systemic antibiotics. Three-month results of a randomized, prospective, controlled clinical study. SchweizMonatsschrZahnmed 2013;123(6):532–44.
- 14 Soukos NS, Goodson JM. Photodynamic therapy in the control of oral biofilms.Periodontol 2000.2011; 55:143–166.
- 15 Raab O. The effect of fluorescent agents on infusoria.Z Biol. 1900; 39:524–526.
- 16 Dougherty TJ, Kaufman JE, Goldfarb A,Weishaupt KR, Boyle D, MittlemaA.Photoradiation therapy for the treatment of malignant tumors. Cancer Res 1978; 38:2628–35.