CC BY-NC-ND 4.0 · Journal of Health and Allied Sciences NU 2017; 07(04): 037-042
DOI: 10.1055/s-0040-1708734
Original Article

Prescription Pattern of Primary Osteoarthritis in Tertiary Medical Centre

Sowmya Sham Kanneppady
1  Senior Lecturer and Head, Department of Pharmacology, Faculty of Medicine, Lincoln University College, Selangor Darul Ehsan, Malaysia
,
Sham Kishor Kanneppady
2  Senior Lecturer, School of Dentistry, International Medical University, Kuala Lumpur, Malaysia
,
Vijaya Raghavan
3  Head of the Department of Pharmacology, KVG Medical College and Hospital, Kurunjibag, Sullia, Karnataka, India
,
Aung Myo Oo
4  Assistant Professor, Department of Biochemistry, Faculty of Medicine, Lincoln University College, Selangor Darul Ehsan, Malaysia
,
Ohn Mar Lwin
5  Post graduate student, Department of Physiology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia
› Author Affiliations

Abstract

Objectives: Osteoarthritis (OA) is one of the commonest joint/musculoskeletal disorders, affecting the middle aged and elderly, although younger people may be affected as a result of injury or overuse. The study aimed to analyze the data, evaluate the prescription pattern and rationality of the use of drugs in the treatment of primary OA with due emphasis on the available treatment regimens.

Materials and methods: Medical case records of patients suffering from primary OA attending the department of Orthopedics of a tertiary medical centre were the source of data. The study was carried out prospectively for a period of 20 months (from December 2012 to July 2014).

Results: 296 case records were collected in which the total number of drugs prescribed were 550. OA was more common in females (51.7%) and was more prevalent in the age group of 30–40 years (39%). Out of 550 drugs prescribed, Aceclofenac was the most frequently prescribed NSAID (29%) followed by Diclofenac (23%). Nimesulide and Paracetamol was the most commonly prescribed fixed dose combination (53). Among gastroprotectives, Ranitidine figured in 66 prescriptions. Glucocorticoids were prescribed orally and intraarticularly in 17 and 14 cases respectively. Dietary supplements like Calcium+Vitamin D (42) and Glucosamine Sulfate + Chondroitin Sulfate complex (19) were also prescribed.

Conclusion: The above study highlights the rational use of therapeutic agents for primary OA.



Publication History

Received: 12 October 2017

Accepted: 06 December 2017

Publication Date:
21 April 2020 (online)

© .

Thieme Medical and Scientific Publishers Private Ltd.
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  • References

  • 1 Kulkarni C, Leena A, Lohit K. A randomised comparative study safety and efficacy of immediate release glucosamine HCL with Glucosamine HCL sustained release formulation in the treatment of knee osteoarthritis: A proof of concept study. J Pharmacol pharmacother 2012; 3:48-54.
  • 2 Egloff C, Hügle T, Valderrabano V. Biomechanics and pathomechanisms of osteoarthritis. Swiss Med Wkly. 2012; 142:w13583.
  • 3 Prevalence and Impact of chronic joint symptoms – seven states. MMWR – Morb Mortal Wkly Rep. 1998; 47:345–351.
  • 4 Guccione AA, Felson DT, Anderson JJ, Anthony JM, Zhang Y, Wilson PW. The effects of specific medical conditions on the functional limitations of elders in the Framingham Study. Am J Public Health. 1994; 84:351–358.
  • 5 Sharma MK, Swami HM, Bhatia V, Verma A, Bhatia S, Kaur G. An epidemiological study of correlates of osteo-arthritis in geriatric population of UT Chandigarh. Indian J Community Med 2007; 32:77-78.
  • 6 Alacqua M, Trifiro G, Cavagna L, Caporali R, Montecucco CM. Prescribing pattern of drugs in the treatment of Osteoarthritis in Italian general practice: The effect of rofecoxib withdrawal. Arthritis Care and Research 2008; 59:568-574.
  • 7 Bishnoi M, Kumar A, Kulkarni SK. Prescription pattern monitoring of management of pattern of osteoarthritis non steroidal anti inflammatory drugs at PUHC, Chandigarh. Indian J. Pharm. Sci., 2006; 68:525-527.
  • 8 Sharma T, Dutta S, Dhasmana DC. Prescribing pattern of NSAIDs in orthopaedic OPD of a tertiary care teaching hospital in Uttaranchal. JK Sci 2006; 8:160-162.