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CC BY-NC-ND 4.0 · Journal of Health and Allied Sciences NU 2016; 06(02): 076-078
DOI: 10.1055/s-0040-1708647
Case Report

Dialysis Dependent 'Double Positive Disease' Responding To Immunosuppression: A Case Report

Shashidhar Baikunje
1   Associate Professor & HOD, Department of Nephrology, K. S. Hedge Medical Academy, Nitte University, Mangalore, Karnataka, India
,
Mahesha Vankalakunti
2   Consultant Renal Histopathologist, Manipal Hospital, Bengaluru, Karnataka, India
,
Adithi Bhandary
3   Senior Resident, Department of Medicine, K. S. Hedge Medical Academy, Nitte University, Mangalore, Karnataka, India
,
P.S. Prakash
4   Professor and HOD, Department of Medicine, K. S. Hedge Medical Academy, Nitte University, Mangalore, Karnataka, India
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Abstract

The outcome of patients with crescentic nephritis and the presence of both ANCA and anti GBM disease (double positive disease) is controversial. Initial data supported the view that this condition has a more favorable prognosis than anti GBM disease but larger and more recent series found much worse renal outcome especially in patients with severe renal failure requiring dialysis. We present a case with severe renal failure due to double positive disease who recovered renal function with aggressive immunosuppression including steroids, cyclophosphamide and plasma exchange.

Keywords

anti-GBM disease - plasma exchange - vasculitis


Publication History

Received: 08 June 2015

Accepted: 05 May 2016

Article published online:
22 April 2020

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