CC BY-NC-ND 4.0 · Journal of Health and Allied Sciences NU 2016; 06(02): 057-062
DOI: 10.1055/s-0040-1708642
Review Article

Remineralizing and Anticariogenic Benefits of Puremilk - A Review

Ishani Vakil
1   Post graduate student, Department of Pedodontics & Preventive Dentistry, A. B. Shetty Memorial Institute of Dental Sciences, Mangalore
,
Vabitha Shetty
2   Professor and Post Graduate, Department of Pedodontics & Preventive Dentistry, A. B. Shetty Memorial Institute of Dental Sciences, Mangalore
,
Amitha M. Hegde
3   Senior Professor and H.O.D, Department of Pedodontics & Preventive Dentistry, A. B. Shetty Memorial Institute of Dental Sciences, Mangalore
› Author Affiliations

Abstract

Caries initiation is associated with demineralization of the subsurface tooth enamel. At this early stage, the caries lesion is reversible via a remineralization process involving the diffusion of calcium and phosphate ions into the subsurface lesion to restore the lost tooth structure. However, children with high caries risk who have an increased and/or repeated episodes of demineralization require additional strategies to enhance remineralization. Today bioactive agents based on milk products have been developed in order to release elements that enhance remineralization of the enamel and dentine under cariogenic conditions. However, there is limited information on the remineralization potential of milk and milk products.



Publication History

Received: 17 July 2015

Accepted: 05 March 2016

Article published online:
22 April 2020

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Thieme Medical and Scientific Publishers Private Ltd.
A-12, Second Floor, Sector -2, NOIDA -201301, India

 
  • References

  • 1 Hurley WL. Human milk and lactation. [Online]. 2002[cited 2005 Sep 15]; Available from: URL:http://www.classes.anci.uiuc.edu/ansc438
  • 2 GartnerLM, Black LS, Eaton AP, Lawrence RA, Naylor AJ, Neifert EM, OHare D, Schanler RJ, Georgieff M, Piovanetti Y, Queenan J. Breastfeeding and the use of human milk. Pediatrics, 100(6):1035- 9,1997
  • 3 Lonnerdal B. Nutritional and physiological significance of human milk proteins. Am J clin Nutr 2003; 77(suppl):1537S-43S.
  • 4 Oshiro M, Yamaguchi K, Takamizaw T, Inage H, Watanabe T, Irokawa A, Ando S, Miyazaki M. Effect of CPP-ACP paste on tooth mineralization - An FE-SEM study. Journal of Oral Sciences 2007; 49(2):115-120.
  • 5 Harper DS, Osborn JC, Hefferren JJ, Clayton R. Cariostatic evaluation of cheeses with diverse physical and compositional characteristics. Caries Research 1986; 20:123-30.
  • 6 Aimutis WR. Bioactive properties of milk proteins with particular focus on anticariogenesis. J Nutr 2004; 134:989S–995S.
  • 7 Bowen WH, Pearson SK. Effect of milk on cariogenesis. Caries Res, 27:461-6, 1993.
  • 8 Hurley WL. Milk Composition [Online]. 2002[cited 2005 Sep 15]; Available from: URL:http://www.classes.ansci.uiuc.edu/ansc438.
  • 9 Rugg-Gunn AJ, Roberts GJ, and Wright WG: Effect of human milk on plaque pH in situ and enamel dissolution in vitro compared with bovine milk, lactose, and sucrose. Caries Res 1985;19:327-34
  • 10 Birkhed D, Imfeld T, Edwardsson S: pH changes in human dental plaque from lactose and milk before and after adaptation. Caries Res 1993; 27:43-50.
  • 11 Featherstone JD. The science and practice of caries prevention. Journal of American Dental Association 2000; 131:887-99.
  • 12 Featherstone JD. The continuum of dental caries-evidence for dynamic disease process. Journal of Dental Research 2004; 83:C39- C42. [Spec Iss C]
  • 13 Reynolds EC. Anticariogenic complexes of amorphous calcium phosphate stabilized by casein phosphopeptides: a review. Spec Care Dentist 1998; 18:8-16.
  • 14 Rahiotis C, Vougiouklakis G. Effect of a CPP-ACP agent on the demineralization and remineralization of dentine in vitro. Journal of Dentistry 2007; 35:695-698.
  • 15 Reynolds EC. Casein phosphopeptide-amorphous calcium phospate and the remineralization of enamel. US DENTISTRY 2006:51-54.
  • 16 Bowen WH, Pearson SK. Effect of milk on cariogenesis. Caries Res,27:461-6. 1993
  • 17 Birkhed D, Imfeld T, Edwardsson S. pH changes in human dental plaque from lactose and milk before and after adaptation. Caries Res, 27:43- 50, 1993.
  • 18 Erickson PR, Mazhari E. Investigation of the role of human breast milk in caries development. Pediatr Dent,21:86-90,1999
  • 19 Ribeiro NME, Ribeiro MAS. Breastfeeding and early childhood caries: a critical review. J pediatr (Rio J), 80(5 Suppl0): S199-210, 2004.
  • 20 Seow WK. Biological mechanisms of early childhood caries. Community Dent Oral Epidemiol, 26 Suppl 1:8-27, 1998.
  • 21 Rugg-Gunn a J, Roberts G J, Wright W G. Effect of human milk on plaque in situ and enamel dissolution in vitro compared with bovine milk, lactose and sucrose. Caries Research 1985:19; 327-334.
  • 22 Warner E A, Kanekanian A D, Andrews A T. Bioactivity of milk proteins: Anticariogenicity of whey proteins. International Journal of dairy remineralization technologies show promise as an adjunctive treatments to fluoride therapy in the noninvasive management of early carious lesions by CPP-ACP complex. Remineralizatiom of early carious lesion by CPPACP complex may continue to emerge in importance as fluoride did in the past for caries prevention and reduction. technology 2001:54:4;151-153
  • 23 Paula Moynihan. Food and factors that protect against dental caries. Nutrition Bulletin 2000;25(4):281-286
  • 24 Goldman AS. The immune system of human milk: antimicrobial, antiinflammatory, and immunomodulating properties. Pediatr Infect Dis J 1993; 12:664–72.
  • 25 Jacobi. The dentition and its dearrangement course of lectures delivered in New York Medical College, 1862.
  • 26 Vienna. Cariogenic potential of milk. Thesis of Indiana School of Dentistry, 1971.
  • 27 Weiss ME, Bibby BG: Effect of milk on enamel solubility. Arch Oral Biol 1966; 11:49-57.
  • 28 Tandon S, Shankar M, Gopinath VK, Moorthy K. Comparitive evaluation of cariogenic potential of different types of milk and milk formula in pre-school children. J Indian SocPedoPrev Dent 1997; 15: 2:64-68.
  • 29 Herod EL. The effect of cheese on dental caries: a review of the literature. Australian Dental Journal 1991; 36: 120-35.
  • 30 Hegde AM, Naik N. Comparison of salivary calcium, phosphate and alkaline phosphatase levels in children with early childhood caries after administration of milk, cheese and GC tooth mousse. An in vivo study. Journal of Clinical Pediatric Dentistry. 2014; 38(4).
  • 31 Petti. S, Simonetti R, D'ArcaSimonetti A. The effect of milk and sucrose consumption in 6- to 11- year old Italian school children. Eur. J. Epidemiol 1997; 13:659-664.
  • 32 Petridou E, Athanassouli t, Panagopoulos H, Revinthi K. Sociodemographic and dietary factors in relation to dental health among Greek adolescents. Community Dent. Oral Epidemiol 1996; 24: 307-311
  • 33 Papas A, Joshi, Belangar A J, Kent R L, Palmer C A, Depaola P F. Dietary models of root caries. Am. J Clin. Nutr. 1995: 61: 417S-422S.
  • 34 Moynihan. Foods and factors that protect against dental caries. Nutr. Bull. 2000; 25:281-286.
  • 35 Kashket S, Depaola D P. Cheese consumption and the development and progression of dental caries. Nutr. Rev 2002; 60: 97-103.
  • 36 Johansson I. Milk and dairy products: possible effects on dental health. Scan J Nutr Rev. 2002; 46:119-122.
  • 37 Lönnerdal B, Forsum E, Hambraeus L. A longitudinal study of the protein, nitrogen and lactose contents of human milk from Swedish well-nourished mothers. Am J ClinNutr 1976; 29:1127–33?
  • 38 Patton S, Houston GE. A method for isolation of milk fat globules. Lipids 1986; 21:170–174.
  • 39 Kunz C, Lönnerdal B. Human-milk proteins: analysis of casein and casein subunits by anion-exchange chromatography, gel electrophoresis, and specific staining methods. Am J ClinNutr 1990; 51:37–46?
  • 40 Kunz C, Lönnerdal B. Re-evaluation of the whey proteicasein ratio of human milk. ActaPaediatr 1992; 81:107–12.
  • 41 Reynolds EC, Cai F, Shen P, Walker GD. Retention in plaque and remineralization of enamel lesions by various forms of calcium in mouthrinse or sugar-free chewing gum.J Dent Res2003;82:206-11.
  • 42 Bowen WH, Lawrence RA: Comparison of the cariogenicity of cola, honey, cow milk, human milk, and sucrose. Pediatrics 2005; 116: 921–926.
  • 43 Gardener DE, Norwood JR, Eisenson JE: At-will breast feeding and dental caries: four case reports. J Dent Res 1977; 44:186–191. 44.Weerheijm KL, Uyttendaele-Speybrouck BFM, Euwe HC, Groen HJ: Prolonged demand breast-feeding and nursing caries. Caries Res 1998; 32:46–50.
  • 45 Matee MIN, van't Hof MA, Maselle SY, Mikx FHM, van PalensteinHelderman WH: Nursing caries, linear hypoplasia and weaning habits in Tanzanian infants. Community Dent Oral Epidemiol 1994; 22:289–291.
  • 46 Reynolds EC, Cai F, Shen P, Walker GD. Retention in plaque and remineralization of enamel lesions by various forms of calcium in a mouthrinse or sugar-free chewing gum. J Dent Res. 2003; 82(3):206-11.