Nuklearmedizin 2020; 59(02): 159
DOI: 10.1055/s-0040-1708330
Wissenschaftliche Poster
PET, SPECT & Co. III
© Georg Thieme Verlag KG Stuttgart · New York

Metaanalysis of associations between FDG uptake measured as standardized uptake value (SUV) and HIF-1α expression in solid tumors

J Steinacker
1   Universitätsklinikum Ulm, Nuklearmedizin, Ulm
,
S Schmidt
2   Universitätsklinikum Ulm, Radiologie, Ulm
,
V Prasad
1   Universitätsklinikum Ulm, Nuklearmedizin, Ulm
,
AJ Beer
1   Universitätsklinikum Ulm, Nuklearmedizin, Ulm
,
A Wienke
3   Martin-Luther-Universität, Institut für Medizinische Epidemiologie, Halle (Saale)
,
A Surov
2   Universitätsklinikum Ulm, Radiologie, Ulm
› Author Affiliations
Further Information

Publication History

Publication Date:
08 April 2020 (online)

 

Ziel/Aim Hypoxia-inducible factor (HIF)-1α plays a key role in hypoxic adaptation of tumor cells. HIF-1α is overexpressed in solid tumor, directs the glucose metabolism pathway from oxidative to anaerobic pathway thereby reducing the oxygen consumption, decreases free radical level and thence prevents cancer cell death. There are inconsistent data about relationships between FDG-PET and HIF-1α. The purpose of the present analysis was to provide evidence regarding associations between FDG uptake measured as standardized uptake value (SUV) and HIF-1α expression in solid tumors.

Methodik/Methods MEDLINE library, SCOPUS and EMBASE data bases were screened for relationships between SUVmax and HIF-1α up to August 2019. Overall, 21 studies with 1154 patients were identified. The following data were extracted from the literature: authors, year of publication, number of patients, and correlation coefficients.

Ergebnisse/Results Correlation coefficients between SUV and HIF-1α ranged from −0.51 to 0.71. The pooled correlation coefficient was 0.27, (95% CI = [0.14; 0.41]). Furthermore, correlation coefficients for specific tumor entities were calculated. For this sub-analysis, data for primary tumors with more than two reports were included. The calculated correlation coefficients in the analyzed subgroups were as follows: head and neck squamous cell carcinoma: ρ = 0.25 (95% CI = [0.07; 0.42]); non-small lung cell cancer: ρ = 0.27 (95% CI = [−0.14; 0.67]); uterine cervical cancer: ρ = −0.09 (95% CI = [- 0.89; 0.71]); thymic tumors: ρ = 0.39 (95% CI = [0.04; 0.58]).

Schlussfolgerungen/Conclusions Published literature suggests wide heterogeneity and weak correlation between intensity of FDG uptake measured as SUVmax and expression of HIF-1α both in solid tumors in general and also in specific tumor subgroups. Because HIF-1α is a very important theranostic target, prospective state of the art studies are needed to elucidate the true potential of FDG PET in assessment of HIF-1α activity in solid tumors.