Nuklearmedizin 2020; 59(02): 147
DOI: 10.1055/s-0040-1708301
Wissenschaftliche Poster
Medizinische Physik II
© Georg Thieme Verlag KG Stuttgart · New York

Improving the Diagnosis of Breast Cancer using a dedicated PET/MRI – The EU Project HYPMED

V Schulz
1   Physics of Molecular Imaging System at the Institute of Experimental Molecular Imaging, Physics of Molecular Imaging System, Aachen, Germany
,
D Schug
1   Physics of Molecular Imaging System at the Institute of Experimental Molecular Imaging, Physics of Molecular Imaging System, Aachen, Germany
,
P Gebhardt
1   Physics of Molecular Imaging System at the Institute of Experimental Molecular Imaging, Physics of Molecular Imaging System, Aachen, Germany
,
N Gross-Weege
1   Physics of Molecular Imaging System at the Institute of Experimental Molecular Imaging, Physics of Molecular Imaging System, Aachen, Germany
,
T Nolte
1   Physics of Molecular Imaging System at the Institute of Experimental Molecular Imaging, Physics of Molecular Imaging System, Aachen, Germany
,
M Borgo
2   Futura Composites B.V., Heerhugowaard, The Netherlands
,
S Aussenhofer
3   Noras MRI Products, Hoechberg, Germany
,
A Salomon
4   Oncology Solutions, Philips Research, Eindhoven, The Netherlands
,
D Schaart
5   Delft University of Technology, Delft, The Netherlands
,
KJ Langen
6   Research Centre Jülich, Institute of Neuroscience and Medicine (INM-4), Jülich, Germany
,
C Kuhl
7   Clinic of Interventional Radiology, RWTH Aachen University, Aachen
,
B Weissler
1   Physics of Molecular Imaging System at the Institute of Experimental Molecular Imaging, Physics of Molecular Imaging System, Aachen, Germany
› Author Affiliations
Further Information

Publication History

Publication Date:
08 April 2020 (online)

 

Ziel/Aim The development of commercial whole body PET/MRI systems has been guided by PET/CT determining the spatial resolution and system sensitivity of clinical PET systems. The H2020 EU project HYPMED aims to overcome these limitations for breast cancer imaging by developing a PET-insert for a clinical 1.5T MRI with a homogeneous spatial resolution of ~1.2 mm and an up to fourfold higher sensitivity.

Methodik/Methods The HYPMED insert consists of a RF receive coil and two highly integrated PET detector rings, supporting DCE MRI and PET/MRI guided biopsy. Each detector ring consists of 28 detector stacks with an axial FOV of ~100 mm. A detector stack consists of a 3-layer crystal array and a MR compatible sensor tile, enabling a homogeneous spatial resolution across the two FOVs. The novel sensor tile contains 144 channels from DPC-3200 (Philips) with a sensitive area of ~48×48 mm^2. The detector is the next evolution of our preclinical technology [1].

Ergebnisse/Results GATE simulations of the NCAT phantom have been used to investigate the sensitivity of the HYPMED insert in comparison to a whole-body PET (Philips GEMINI TF). The simulation shows a nearly fourfold sensitivity when taking gamma photon attenuation into account. The designed new sensor tile has been built and characterized. Measured flood histograms show that all 3781 crystals of the 3-layer crystal design could be identified. Excellent time-of-flight capability and energy resolution of <270ps and <11 % using an LYSO array of 4x4x16 mm^3 crystals was achieved. The MR compatibility was characterized and shows the full operation of PET and no deterioration of the 1.5T MRT during simultaneous operation.

Schlussfolgerungen/Conclusions The new digital HYPMED detector has been characterized and shows the desired performance. A fourfold gain in sensitivity could be predicted. Further details of the developments will be shown during the conference.

 

  • Literatur/References

  • 1 Weissler. et al. Ieee Tmi , 34 . (11) 2015; ): 2258-2270 .