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Synthesis 2020; 52(17): 2563-2571
DOI: 10.1055/s-0040-1707391
DOI: 10.1055/s-0040-1707391
paper
Synthesis and Structure of 1-Substituted Semithioglycolurils
The Scientific Schools Development Program by the Zelinsky Institute of Organic Chemistry is gratefully acknowledged.Further Information
Publication History
Received: 26 March 2020
Accepted after revision: 17 April 2020
Publication Date:
25 May 2020 (online)
Abstract
Two methods for the synthesis of previously unavailable 1-substituted semithioglycolurils were developed. These methods consist of the cyclocondensation of 1-substituted ureas with 4,5-dihydroxy- or 4,5-dimethoxyimidazolidine-2-thione or glyoxal, followed by the reaction of the resulting 1-substituted 4,5-dihydroxyimidazolidine-2-ones with HSCN in a two-step one-pot procedure. Two of the desired semithioglycolurils were obtained as conglomerates.
Key words
semithioglycolurils - cyclocondensation - heterocycles - urea derivatives - thiourea derivatives - glyoxalSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0040-1707391.
- Supporting Information
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