Synthesis 2020; 52(23): 3684-3692
DOI: 10.1055/s-0040-1707237
paper
© Georg Thieme Verlag Stuttgart · New York

Catalytic Asymmetric Substitution Reaction of 3-Substituted 2-Indolylmethanols with 2-Naphthols

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We appreciate the financial support from the National Natural Science­ Foundation of China (21772069 and 21831007), Six Kinds of Talents Project of Jiangsu Province (SWYY-025), TAPP, and Undergraduate Students Project of JSNU.
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Publication History

Received: 10 June 2020

Accepted after revision: 13 July 2020

Publication Date:
17 August 2020 (online)


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§ These authors contributed equally to the work

Abstract

A catalytic asymmetric substitution of 3-substituted 2-indolylmethanols with 2-naphthols has been established under the catalysis of chiral phosphoric acid. By this approach, a series of structurally diversified triarylmethane derivatives were obtained in moderate to high yields with good enantioselectivities (up to 97% yield, 95:5 er). This approach not only enriches the chemistry of 2-indolylmethanol-inolved catalytic asymmetric substitutions, but also provides a useful method for the enantioselective synthesis of chiral triarylmethane derivatives.

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