Synthesis of N-Aryl-4-arylhexahydroquinoline Derivatives by Reaction of Cyclic Enaminones with Arylidenemalononitriles in DMSO

Abstract

The reaction of cyclic enaminones with arylidenemalono­nitriles was carried out in the presence of 13X molecular sieves in dimethyl sulfoxide. Under these mild reaction conditions, various bioactive N-aryl-4-arylhexahydroquinoline derivatives were obtained in high yields without the necessity of using transition-metal catalyst, organobase, or reflux conditions.

Key words

dimethyl sulfoxide - molecular sieves - cyclic enaminones - arylidenemalononitriles - N-aryl-4-arylhexahydroquinolines

Publication History

Received: 23 September 2020

Accepted after revision: 12 November 2020

Article published online:
08 December 2020

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