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DOI: 10.1055/s-0040-1705982
Iodine-Mediated Facile One-Pot Access to N-Aryl-2-benzoxazolamines
This work was supported by Japan Society for the Promotion of Science (JSPS KAKENHI JP 17K07776 to S.T. and JP 17H06092).
Abstract
Facile, iodine-mediated access to N-aryl-2-benzoxazolamines has been achieved in a one-pot manner under mild reaction conditions. Reaction of 2-aminophenols and aryl isothiocyanates afforded N-aryl-2-benzoxazolamines in the presence of molecular iodine and pyridine in tetrahydrofuran at room temperature in moderate to excellent yields.
Key words
iodine - benzoxazolamine - one-pot synthesis - cyclodesulfurization - transition-metal-freeSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0040-1705982.
- Supporting Information
Publication History
Received: 12 October 2020
Accepted after revision: 11 November 2020
Article published online:
24 November 2020
© 2020. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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