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CC BY-NC-ND 4.0 · Journal of Health and Allied Sciences NU 2015; 05(03): 082-086
DOI: 10.1055/s-0040-1703917
Original Article

Randomised, single blinded, controlled, prospective study comparing ketamine, lignocaine and chlorhexidine gargle in prevention of post-operative sore throat

Sumalatha R. Shetty
1   Professor, Department of Anaesthesiology, K.S. Hegde Medical Academy, Nitte University, Mangalore, Karnataka, India
,
Karan Pratap Singh Panaych
2   Post Graduate, Department of Anaesthesiology, K.S. Hegde Medical Academy, Nitte University, Mangalore, Karnataka, India
,
Raveendra U. S.
3   Professor, Department of Anaesthesiology, K.S. Hegde Medical Academy, Nitte University, Mangalore, Karnataka, India
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Abstract

Background: Postoperative sore throat is a common complaint in patients after extubation and can be distressing to the patients. Hence we aimed to compare efficacy of lignocaine, ketamine and chlorhexidine gargle for the control of postoperative sore throat.

Materials and Methods: After institutional ethical committee clearance, 100 patients were allotted into 4 groups of 25 each in this randomized, double blind, control study. The study solution for gargle in Group L, Group C and Group K contained 50mg lignocaine, 30mg chlorhexidine and 50 mg ketamine in 30ml sterile water respectively while in Group W it was 30ml of sterile water. The study solution was given 5 minutes before induction and the patients were made to gargle it for 30 seconds. The post-operative sore throat (POST) grading was done at 0, 2, 6 and 24 hours after extubation.

Results: At 0 hour, there was a significant lower grades of POST in Group K as compared to Group W (p=0.011). At the 4 hour interval, the grades of POST were significantly lower in group K (p=0.001) and Group L (p<0.001) whencompared to Group C.At the 24 hour time interval, the grades of POST were lower in Group L (p=0.007) and Group K (p<0.001) when compared to Group C. At the same time interval, significantly lower grades of POST in Group W was seen compared to Group C (p=0.001). At the end of all time intervals there was no statistical significant difference in the severity of POST in Group L and Group K. There were no significant haemodynamic changes in any of the groups.

Conclusion: Ketamine and Lignocaine gargles are effective in the reduction of postoperative sore throat without any changes in haemodynamics.

Keywords

Lignocaine - Ketamine - Chlorhexidine - Sore throat


Publication History

Article published online:
22 April 2020

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