CC BY-NC-ND 4.0 · Journal of Health and Allied Sciences NU 2014; 04(04): 120-125
DOI: 10.1055/s-0040-1703850
Review Article

ROLE OF PHYTOCHEMICALS IN ORAL POTENTIALLY MALIGNANT DISORDERS : A REVIEW

Ananya Madiyal
1  Post Graduates, A.B. Shetty Memorial Institute of Dental Sciences, Nitte University, Mangalore - 575 018, India.
,
Vidya Ajila
2  Reader, A.B. Shetty Memorial Institute of Dental Sciences, Nitte University, Mangalore - 575 018, India.
,
Subhas G Babu
3  Professor & HOD, A.B. Shetty Memorial Institute of Dental Sciences, Nitte University, Mangalore - 575 018, India.
,
Shruthi Hedge
4  Lecturers, Department of Oral Medicine & Radiology, A.B. Shetty Memorial Institute of Dental Sciences, Nitte University, Mangalore - 575 018, India.
,
Harini Keshavaiah
5  Lecturers, Department of Oral Medicine & Radiology,Department of Periodontics, A.B. Shetty Memorial Institute of Dental Sciences, Nitte University, Mangalore - 575 018, India.
,
Priyadharshini Alva M.
6  Post Graduates, A.B. Shetty Memorial Institute of Dental Sciences, Nitte University, Mangalore - 575 018, India.
› Author Affiliations

Abstract

Oral cancer is a major global health concern and poses a challenge to diagnostic and therapeutic aspects of healthcare services. Various oral lesions like leukoplakia, erythroplakia, lichen planus and oral submucus fibrosis categorized as orally potential malignant disorders have shown increased incidence of malignant transformation. Free radicals are highly reactive chemical species with capacity to damage nucleic acids, proteins and lipids and bring about changes of clinical significance. Antioxidants help in scavenging these free radicals and prevent disease progression. Naturally occurring phytochemicals play an important role in preventing oxidative stress and protect the cells from damage by free radicals.



Publication History

Publication Date:
26 April 2020 (online)

© .

Thieme Medical and Scientific Publishers Private Ltd.
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  • References

  • 1 Warnakulasuriya S. Global epidemiology of oral and pharyngeal cancer. Oral Oncology 2009; 45:309-16.
  • 2 Ferley J, Parkin DM. GLOBOCAN 2002. Cancer incidence, Mortality and Prevalence Worldwide. IARC Cancer Base (2002 estimates). Lyon IARC press 2004.
  • 3 Tuyns AJ, Hiramaya T. World Health Organisation Epidemiologic Studies of the Tumors of the Mouth and Jaw. J Dent Res 1966; 45:535-45.
  • 4 Melhotra R, Pandya S, Chaudary AK, Kumar M, Singh M. Prevalence of Oral Pre-malignant and Malignant Lesions at a Tertiary Level Hospital in Allahabad, India. Asian Pacific J Cancer Prev 2008; 9:263-6.
  • 5 Warnakulasuriya S, Johnson NW, van der Waal I. Nomenclature and Classification of Potentially Malignant Disorders of the Oral Mucosa. J Oral Pathol Med 2007; 36:575-80.
  • 6 World Health Organization Collaborating Centre for Oral Precancerous Lesions. Definition of leukoplakia and related lesions: an aid to studies on oral precancer. Oral Surg Oral Med Oral Pathol1978; 46:518-39.
  • 7 George A, Sreenivasan B, Sunil S, Varghese S, Thomas J, Gopakumar D, Varghese M. Potentially Malignant Disorders of Oral Cavity. OMPJ 2011; 2:95-100.
  • 8 Reibel J. Prognosis of Oral Pre-malignant lesions: Significance of Clinical, Histopathological and Molecular Biological Characteristics. Crit Rev Oral Biol Med 2003; 14:47-62.
  • 9 Iannitti T, Rottigni V, Palmieri B. Role of Free Radicals and Antioxidant Defences in Oral Cavity-Related Pathologies. J Oral Pathol Med 2012; 649-61.
  • 10 Khan SG, Katiyar SK, Agarwal R, Mukhtar H. Enhancement of Antioxidant and Phase II Enzymes by Oral Feeding of Green Tea Polyphenols in Drinking Water to SKH-1 Hairless Mice: Possible Role in Cancer Chemoprevention. Cancer Res 1992; 52:4050-2.
  • 11 Peto R, Doll R, Buckley JD, Sporn MB. Can Dietary Beta-carotene Materially Reduce Cancer Rates? Nature 1981; 290:201-8.
  • 12 Gaby SK, Bendich A, Singh VN, Machlin LJ (eds.) Vitamin Intake and Health. New York: Marcel Dekker 1991; 17-27.
  • 13 Rui Hai Liu. Potential Synergy of Phytochemicals in Cancer Prevention: Mechanism of Action. J Nutr 2004; 134:34795-855.
  • 14 Kaugras EG, Silverman S, Lovas JGL, Thompson JS, Brandt RB, Singh VN. Role of Antioxidant Supplements in the Treatment of Human Oral Leukoplakia. Oral Surgery Oral Medicine Oral Pathology 1996; 81:5-14.
  • 15 Agarwal S, Rao AV. Tomato Lycopene and Low Protein Lipoprotein Oxidation: A Human Dietary Intervention Study. Lipids 1998; 33:981-4.
  • 16 Matsushima NR, Shidoji Y, Nishiwaki S, Yamada T, Moriwaki H, Muto Y. Suppression by carotenoids of microcystin-induced morphological changes in mouse hepatocytes. Lipids 1995; 30:1029-34.
  • 17 Levy J, Bosin E, Feldman B, Giat Y, Miinster A, Danilenko M, Sharoni Y. Lycopene is a More Potent Inhibitor of Human Cancer Cell Proliferation than Either Alpha-carotene or Beta-carotene. Nutr Cancer 1995; 24:257-66.
  • 18 Sunderraj S, Sharma R, Agarwal V, Narang P, Reddy YG, Sharma AK. An In vivo Study to Determine the Efficacy of Lycopene as Compared to Multi-vitamin Preparation in the Treatment of Oral Sumucus Fibrosis. J Iindian Aca Oral Med Radiol 2012; 24:190-3.
  • 19 Nijveldt RJ, van Nood E, van Hoorn DEC, Boelens PG, van Norren K, van Leeuwen PAM. Flavonoids: A Review of Probable Mechanism of Action and Potential Applications. Am J Clin Nutr 2001; 74:418-25.
  • 20 Korkina LG, Afanas'ev IB. Antioxidant and Chelating Properties of Flavonoids. Adv Pharmacol 1997; 38: 151–63.
  • 21 van Acker SA, Tromp MN, Haenen GR, van der Vijgh WJ, Bast A. Flavonoids as Scavengers of Nitric Oxide Radical. Biochem Biophys Res Commun 1995; 214: 755–9.
  • 22 Chang WS, Lee YJ, Lu FJ, Chiang HC. Inhibitory Effects of Flavonoids on Xanthine Oxidase. Anticancer Res 1993; 13: 2165–70.
  • 23 Bennett JP, Gomperts BD, Wollenweber E. Inhibitory Effects of Natural Flavonoids on Secretion from Mast Cells and Neutrophils. Arzneimittelforschung 1981; 31:433-7.
  • 24 de Ghroot H, Rauen U. Tissue Injury by Reactive Oxygen Species and the Protective Effects of Flavonoids. Fundam Clin Pharmacol 1998; 12:249-55.
  • 25 Dragsted LO, Strube M, Larsen JC. Cancer-protective Factors in Fruits and Vegetables: Biochemical and Biological Background. Pharmacol Toxicol 1993; 72:116-35.
  • 26 Waladkhani AR, Clemens MR. Effect of Dietary Phytochemicals on Cancer Development. Int J Mol Med 1998; 1:747-53.
  • 27 Shetti A, Keluskar V, Aggarwal A. Antioxidants: Enhancing Oral and General Health. JIAOMR 2009; 21:1-6.
  • 28 Kaugras EG, Silverman S, Lovas JGL. A Clinical Trial of Antioxidant Supplements in the Treatment of Oral Leukoplakia. Oral Surg Oral Med Oral path 1994; 78:462-8.
  • 29 Mathews-Roth MM. Beta-carotene: Clinical Aspects. In: New Protective Roles for Selected Nutrients. Alan R Liss 1989; 17-38.
  • 30 Stich HF, Rosin MP, Hornby AP. Remission of Oral Leukoplakias and Micronuclei in the Tobacco/betel Nut Quid Chewers Treated with Beta-carotene and with Beta-carotene plus Vitamin A. Int J Cancer 1988; 42:195-9.
  • 31 Benner SE1, Winn RJ, Lippman SM, Poland J, Hansen KS, Luna MA, Hong WK. Regression of Oral Leukoplakia with Alpha-tocopherol: A Community Clinical Oncology Program Chemoprevention Study. J Natl Cancer Inst 1993; 85:44-7.
  • 32 Singh M, Krishnappa R, Bagewadi A, Keluskar V. Efficacy of Oral Lycopenein the Treatment of Oral Leukoplakia. Oral Oncology 2004; 40:591-6.