EVALUATION OF SALIVARY ENZYMES IN POST MENOPAUSAL WOMEN WITH AND WITHOUT PERIODONTITIS

Santhosh Shenoy B.; Prajnya Shenoy; Avaneendra Talwar; Biju Thomas; K.S. Sharath; Shamila Shetty K.

doi:10.1055/s-0040-1703840

Journal of Health and Allied Sciences NU, Table of Contents

CC BY-NC-ND 4.0 · Journal of Health and Allied Sciences NU 2014; 04(04): 088-091
DOI: 10.1055/s-0040-1703840

Original Article

EVALUATION OF SALIVARY ENZYMES IN POST MENOPAUSAL WOMEN WITH AND WITHOUT PERIODONTITIS

Authors

Santhosh Shenoy B.

¹Readers, Department of Periodontics, A.B. Shetty Memorial Institute of Dental Sciences, Nitte University, Mangalore – 575 018
Prajnya Shenoy

²Student (BDS), Department of Periodontics, A.B. Shetty Memorial Institute of Dental Sciences, Nitte University, Mangalore – 575 018
Avaneendra Talwar

³Readers,Department of Periodontics, A.B. Shetty Memorial Institute of Dental Sciences, Nitte University, Mangalore – 575 018
Biju Thomas

⁴Professor & HOD, Department of Periodontics, A.B. Shetty Memorial Institute of Dental Sciences, Nitte University, Mangalore – 575 018,Mangalore
K.S. Sharath

⁵Professor & HOD, Department of Periodontics, Srinivas Institute of Dental Sciences, Mukka,Mangalore
Shamila Shetty K.

⁶Reader, Department of Periodontics, A.J. Institute of Dental Sciences, Mangalore

Abstract

PDF Download

Abstract

Aim: To compare the levels of Lactate dehydrogenase (LDH) and alkaline phosphatase (ALP) in post-menopausal women with and without periodontitis

Methodology: A cross-sectional pilot study was conducted. A total of 50 postmenopausal women were recruited and categorized into two groups based on their periodontal status. Their salivary samples were collected and subjected to Lactate dehydrogenase (LDH) and alkaline phosphatase (ALP) estimation in the laboratory

Results: The activity of LDH and ALP were significantly higher in the post-menopausal women with periodontitis than those without periodontitis.

Conclusion: The present study demonstrated post-menopausal women may have exaggerated inflammatory response to dental plaque.

Keywords

Lactate dehydrogenase (LDH) - Alkaline phosphatase (ALP) - post-menopause - periodontitis - saliva

PDF (413 kb)

References

References
1 Van Dyke, T.A., Lester, M.A., Shapira, L. The role of the host response in periodontal disease progression; Implications for future treatment strategies.Journal of Periodontology 1993; Aug Supp:792-806.
2 Yildirim TT, Kaya FA. The Effects of Menopause on Periodontal Tissue. Int Dent Res 2011;3:81-86.
3 Zittermann, A., Schwarz, I., Scheld, K. et al. Physiologic fluctuations of serum estradiol levels influence biochemical markers of bone resorption in young women. The Journal of Clinical Endocrinology & Metabolism 2000; 85:95-101. protected? Hum Reprod 2004;19:2175-79.
5 Mariotti, J.A. Estrogen and extra-cellular matrix influence human gingival fibroblast proliferation and production. Journal of Periodontology 2005; 76:1391-1397.
6 Johnson, R.B., Gilbert, J.A., Cooper, R.C., et al. Effect of estrogen deficiency on skeletal and alveolar bone density in sheep. Journal of Periodontology 2002; 73:383-391.
7 Kugahara T, Shosenji Y, Ohasik. Screening for periodontitis in pregnant women with salivary enzymes. J ObstetGynaecol Res 2008;34(1):40-46.
8 Kaufman E, Lamster IB. Analysis of saliva for periodontal diagnosis- A review. J ClinPeriodontol 2000; 27:453-465.
9 Kinney JS, Ramseier CA, and Giannobile WV. Oral Fluid-Based Biomarkers of Alveolar Bone Loss in Periodontitis. Ann N Y Acad Sci. 2007 March; 1098: 230–251.
10 De La Peña VA, Diz Dios P, Tojo Sierra R. Relationship between lactate dehydrogenase activity in saliva and oral health status.Arch Oral Biol. 2007;52(10):911-5.
11 OzlemDaltaban, Sayagun, BelginBal, KokasalBalos, and MuhittinSerdar. Gingival crevicular fluid, alkaline phosphatase levels in postmenopausal women: Effect of phase I periodontal treatment. J periodontal 2006; 77:67-72.
12 Ramesh A, BhandaryR, Thomas B, D' souza S & Kumari S. Alkaline phosphatase – a diagnostic marker of periodontitis in postmenopausal women – A biochemical study. NUJHS 2013; 3 (4): 3 71-7
13 Reinhardt RA, Payne JB, Maze CA, Patil KD, GallagherSJ, Mattson JS.Influence of Estrogen and Osteopenia/Osteoporosis on Clinical Periodontitis in Postmenopausal Women. J Periodontol 1999;70 (8):823-828.