EVALUATION OF SALIVARY ENZYMES IN POST MENOPAUSAL WOMEN WITH AND WITHOUT PERIODONTITIS
Aim: To compare the levels of Lactate dehydrogenase (LDH) and alkaline phosphatase (ALP) in post-menopausal women with and without periodontitis
Methodology: A cross-sectional pilot study was conducted. A total of 50 postmenopausal women were recruited and categorized into two groups based on their periodontal status. Their salivary samples were collected and subjected to Lactate dehydrogenase (LDH) and alkaline phosphatase (ALP) estimation in the laboratory
Results: The activity of LDH and ALP were significantly higher in the post-menopausal women with periodontitis than those without periodontitis.
Conclusion: The present study demonstrated post-menopausal women may have exaggerated inflammatory response to dental plaque.
KeywordsLactate dehydrogenase (LDH) - Alkaline phosphatase (ALP) - post-menopause - periodontitis - saliva
26 April 2020 (online)
Thieme Medical and Scientific Publishers Private Ltd.
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- 1 Van Dyke, T.A., Lester, M.A., Shapira, L. The role of the host response in periodontal disease progression; Implications for future treatment strategies.Journal of Periodontology 1993; Aug Supp:792-806.
- 2 Yildirim TT, Kaya FA. The Effects of Menopause on Periodontal Tissue. Int Dent Res 2011;3:81-86.
- 3 Zittermann, A., Schwarz, I., Scheld, K. et al. Physiologic fluctuations of serum estradiol levels influence biochemical markers of bone resorption in young women. The Journal of Clinical Endocrinology & Metabolism 2000; 85:95-101. protected? Hum Reprod 2004;19:2175-79.
- 5 Mariotti, J.A. Estrogen and extra-cellular matrix influence human gingival fibroblast proliferation and production. Journal of Periodontology 2005; 76:1391-1397.
- 6 Johnson, R.B., Gilbert, J.A., Cooper, R.C., et al. Effect of estrogen deficiency on skeletal and alveolar bone density in sheep. Journal of Periodontology 2002; 73:383-391.
- 7 Kugahara T, Shosenji Y, Ohasik. Screening for periodontitis in pregnant women with salivary enzymes. J ObstetGynaecol Res 2008;34(1):40-46.
- 8 Kaufman E, Lamster IB. Analysis of saliva for periodontal diagnosis- A review. J ClinPeriodontol 2000; 27:453-465.
- 9 Kinney JS, Ramseier CA, and Giannobile WV. Oral Fluid-Based Biomarkers of Alveolar Bone Loss in Periodontitis. Ann N Y Acad Sci. 2007 March; 1098: 230–251.
- 10 De La Peña VA, Diz Dios P, Tojo Sierra R. Relationship between lactate dehydrogenase activity in saliva and oral health status.Arch Oral Biol. 2007;52(10):911-5.
- 11 OzlemDaltaban, Sayagun, BelginBal, KokasalBalos, and MuhittinSerdar. Gingival crevicular fluid, alkaline phosphatase levels in postmenopausal women: Effect of phase I periodontal treatment. J periodontal 2006; 77:67-72.
- 12 Ramesh A, BhandaryR, Thomas B, D' souza S & Kumari S. Alkaline phosphatase – a diagnostic marker of periodontitis in postmenopausal women – A biochemical study. NUJHS 2013; 3 (4): 3 71-7
- 13 Reinhardt RA, Payne JB, Maze CA, Patil KD, GallagherSJ, Mattson JS.Influence of Estrogen and Osteopenia/Osteoporosis on Clinical Periodontitis in Postmenopausal Women. J Periodontol 1999;70 (8):823-828.