CC BY-NC-ND 4.0 · Journal of Health and Allied Sciences NU 2014; 04(04): 004-009
DOI: 10.1055/s-0040-1703823
Original Article


Njinga NS
1  Lecturers, Department of Pharmaceutical & Medicinal Chemistry, University of Ilorin, Nigeria.
Sule MI
2  Professor, Ahmadu Bello University, Zaria, Nigeria.
Pateh UU
3  Associate Professor & Dean, Faculty of Pharmaceutical 5 Sciences, Ahmadu Bello University, Zaria, Nigeria.
Hassan HS
4  Senior Lecturer, Department of Pharmaceutical & Medicinal Chemistry, Ahmadu Bello University, Zaria, Nigeria.
Ahmad MM
5  Pharmacist, Dr. Gwamna Awan Memorial Hospital, Kakuri, Nigeria.
Abdullahi ST
6  Lecturers, Department of Pharmaceutical & Medicinal Chemistry, University of Ilorin, Nigeria.
Danja BA
7  Lecturer, Department of Chemical Sciences, Faculty of Science, Federal University Kashere, Gombe, Nigeria.
B Bawa
8  Researche Scholar, National Agency for Food and Drugs Administration and Control (NAFDAC), Nigeria.
› Author Affiliations


The phytochemical and antimicrobial activity of the petroleum ether and crude methanol extracts, chloroform and ethyl acetate fractions of the leaves of Lannea kerstingii were investigated. Phytochemical screening revealed the presence of steroids and triterpenes in the petroleum ether extract, steroid, triterpene, flavonoids and tannins in both crude methanol extract and chloroform fraction while the ethyl acetate fraction contained only flavonoids and tannins. The extracts exhibited antimicrobial activities with zones of inhibition ranging from 17.00 to 21.03, 20.10 to 25.24, 25.32 to 34.02 and 22.28 to 27.20 mm for petroleum ether extract, methanol extract, chloroform and ethyl acetate fractions respectively. The minimum inhibitory concentration was between 5 and 10mg/ml, 5mg/ml for the petroleum ether and methanol extract respectively, and between 2.5 and 5 mg/ml, 5mg/ml for the acetate fractions. The minimum bactericidal concentration for all the extracts was 40mg/ml respectively except for chloroform fraction which ranged from 20 to 40mg/ml. The minimum fungicidal concentration for all the extracts was found to be 40mg/ml respectively. This result indicates the broad spectrum antimicrobial potential of L. Kerstingii and justifies the use of this plant in traditional medicine.

Publication History

Publication Date:
26 April 2020 (online)

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Thieme Medical and Scientific Publishers Private Ltd.
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