Download PDF
CC BY-NC-ND 4.0 · Journal of Health and Allied Sciences NU 2014; 04(02): 094-097
DOI: 10.1055/s-0040-1703771
Short Communication

AGE RELATED DIFFERENCE IN THE LIPID PROFILE IN NORMAL HEALTHY WOMEN

Deepti G. I.
1   P.G. Students, Department of Biochemistry K.S. Hegde Medical Academy, Nitte University, Deralakatte Mangalore - 575 018, Karnataka, India
,
Sukanya Shetty
2   Professor & HOD, Department of Biochemistry K.S. Hegde Medical Academy, Nitte University, Deralakatte Mangalore - 575 018, Karnataka, India
,
Ashalatha V. Rao
3   Professor, Department of Biochemistry K.S. Hegde Medical Academy, Nitte University, Deralakatte Mangalore - 575 018, Karnataka, India
,
Sarfraz Ahmad
1   P.G. Students, Department of Biochemistry K.S. Hegde Medical Academy, Nitte University, Deralakatte Mangalore - 575 018, Karnataka, India
› Author Affiliations
› Further Information
  PDF Download Permissions and Reprints

Abstract:

Background and objectives: Lipid disorder is a major risk factor for the progression of coronary artery disease. Age alone is a significant predictor of CVD risk in men and women. Before menopause, women have a much lower risk for cardiovascular events compared with men of their age. Reasons for protection from CVD in premenopausal women are complex, but a significant contribution can be assigned to the greater high-density lipoprotein (HDL) levels in younger women, which is an effect of estrogen.

Methods: Fasting blood samples were collected from 40 healthy individuals (40 females divided into 2 groups according to age). Serum total cholesterol, triglycerides, and HDL- Cholesterol were estimated by enzymatic methods and LDL was calculated by Friedewald's equation.

Results: The result showed increase in jyounger age group.

Conclusion: It can be concluded that serum lipid profile changes can possibly be mediated by changing hormonal profile, especially estrogen which has role in lipid metabolism and indirectly on coronary artery disease.

Keywords:

Coronary artery disease - Friedewald's equation - perimenopausal period


Publication History

Article published online:
24 April 2020

© .

Thieme Medical and Scientific Publishers Private Ltd.
A-12, Second Floor, Sector -2, NOIDA -201301, India

 

  • References:

  • 1 V Bhagya, N R Hemalatha, H B Veeranna, V Banu. Serum lipid profile in prepubertal, reproductive and postmenopausal women. Int J Biol Med Res. 2011; 2(3): 639-642.
  • 2 Jain A, Santoro N. Endocrine mechanisms and management for abnormal bleeding due to perimenopausal changes. Clin Obstet Gynecol. 2005; 48:29.
  • 3 Santoro N, Brown JR, Adel T. Characterization of reproductive References: hormone dynamics in the peimenopausal. J.Clin.Endocrinol Metab. 1996;81:1495.
  • 4 Reyes FI, Winter JS, Faiman C. Pituitary-ovarian relationships preceding the menopause. I. A cross-sectional study of serum folliclestimulating hormone, luteinizing hormone, prolactin, estradiol, and progesterone levels. Am J Obstet Gynecol. 1997; 129:557.
  • 5 Roseff SJ, Bangah ML, Kettel LM. Dynamic changes in circulating 96 NUJHS Vol. 4, No.2, June 2014, ISSN 2249-7110 Nitte University Journal of Health Science Keywords : Coronary artery disease, Friedewald's equation, perimenopausal period. - Sukanya Shetty inhibin levels during the luteal-follicular transition of the human menstrual cycle. J Clin Endocrinol Metab. 1998; 69:1033, 198.
  • 6 Labrie F, Belanger A, Cusan L. Marked decline in serum concentrations of adrenal C19 sex steroid precursors and conjugated androgen metabolites during aging. J Clin Endocrinol Metab. 1997; 82:2396.
  • 7 Burger HG, Dudley EC, Cui J. A prospective longitudinal study of serum testosterone, dehydroepiandrosterone sulfate, and sex hormonebinding globulin levels through the menopause transition. J Clin Endocrinol Metab. 2000; 85:2832.
  • 8 Minino AM, Arias E, Kochanek KD. Deaths: final data for 2000. Natl Vital Stat Rep. 2002; 50:1.
  • 9 Matthews KA, Wing RR, Kuller LH, et al: Influence of the perimenopause on cardiovascular risk factors and symptoms of middle-aged healthy women. Arch Intern Med 1994; 154:2349.
  • 10 Van Beresteijn EC, Korevaar JC, Huijbregts PC. Perimenopausal increase in serum cholesterol: a 10-year longitudinal study. Am J Epidemiol. 1993; 137:383.
  • 11 Jensen J, Nilas L, Christiansen C. Influence of menopause on serum lipids and Lipoprotein. Maturitas. 1990; 12(4):321.
  • 12 Matthews KA, Meilahn E, Kuller LH. Menopause and risk factors for coronary heart disease. N Engl J Med. 1989; 321:641.
  • 13 Jacobs DR Jr., Mebane IL, Bangdiwala SI, et al: High density lipoprotein cholesterol as a predictor of cardiovascular disease mortality in men and women: the follow-up study of the Lipid Research Clinics Prevalence Study. Am J Epidemiol.1990; 131:32.
  • 14 Kannel WB. Metabolic risk factors for coronary heart disease in women: perspective from the Framingham study. Am Heart J. 1987;114:413.
  • 15 Goswami K, Bandyopadhyay A. lipid profile in middle class Bengali population of Kolkata. Indian J clin Biochem. 2000;18(2):127-30.
  • 16 Gandhi B M. lipoprotein composition of normal healthy subjects in northern India. Ind T Med Res. 1982; 75:393-401.
  • 17 Gupta KK, Chaugh S K. Study of lipid profile of Indian children born of parents free from both coronary artery disease and coronary risk. Indian Heart J. 1996;48:545.
  • 18 Notelovitz M, Katz-kamp S. Effect of cyclic estrone sulfate treatment on lipid profiles of postmenopausal women with elevated cholesterol levels. Obstetrics and Gynecology.1990 ;76:65-70.
  • 19 Nebrand C, Lidfelt J, Nyber P, Schersten B. Serum lipids and lipoproteins in relation to endogenous and exogenous female steroids and age. The women's Health in Leend area(WHILA) study. Maurietas. 2004;15;48(2):161-9.
  • 20 Bonithon-Koop C, Scarabin P Y, Darne B, Malniejac A. Menopause related changes in lipoproteins and some other cardiovascular risk factors. Int J epidemiol. 1990;19(1):42-48.
  • 21 Farish E, Fletcher C D. The effects of hormone implants on serum lipoproteins and steroid hormones in bilaterally ooporectomised women. Acta Endocrinol (copenh). 1984;106(1):116-20.