CC BY-NC-ND 4.0 · Journal of Health and Allied Sciences NU 2014; 04(02): 070-080
DOI: 10.1055/s-0040-1703767
Original Article

EVALUATION OF RADIO PROTECTIVE EFFECT OF AVERRHOA CARAMBOLA LEAVES EXTRACT IN WISTAR RATS

Arunachalam Kumar
1  Professor & Head, Department of Anatomy, K.S. Hegde Medical Academy, Nitte University Mangalore - 575 018, Karnataka, India
,
Suchetha Kumari N.
2  Department of Biochemistry, Professor, K.S. Hegde Medical Academy, Nitte University Mangalore - 575 018, Karnataka, India
,
Kavitha K.
3  Lecturer, Department of Anatomy, K.S. Hegde Medical Academy, Nitte University Mangalore - 575 018, Karnataka, India
,
Rojin T. S.
4  Lecturer, Department of Pharmacology, K.S. Hegde Medical Academy, Nitte University Mangalore - 575 018, Karnataka, India
› Institutsangaben

Abstract:

The present study was designed to investigate the radio protective efficacy of ethanolic extract of leaves of the Averrhoa carambola by studying the following parameters: radioprotective effect before and after radiation, estimating the Total Antioxidant Status, haematological parameters, assessing the histopathology of liver and kidney. Extract was given orally at a dose of 450 mg/kg, orally for 15 days prior to and 15 days after radiation (2 Gy). The rats were kept under observation for 15 days for any sign of radiation sickness, morbidity, behavioural toxicity, urination and defecation pattern or mortality, which showed no changes. The haematological parameters showed a significant decrease in the irradiated rat when compared with the control group. Antioxidant activity revealed from the data obtained in the present study showed that A.carambola leaves ethanolic extract possess good antioxidant activity. Histopathological changes in the irradiated liver and kidney sections showed improved cellular architecture when compared to the normal. The present study suggests that supplementation with Averrhoa carambola has potent antioxidant activity and act as probable radioprotector against gamma radiation induced oxidative damage.



Publikationsverlauf

Publikationsdatum:
24. April 2020 (online)

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Thieme Medical and Scientific Publishers Private Ltd.
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  • References:

  • 1 Oliveira VPV, Cavalcanti FS, Bezerra CLF & Pinto JL (1989). Plantas medicinais: consideracoes ecologicas e uso popular. Salusvita, 8: 49- 58.
  • 2 Pio-Correa M (1931). Dicionário de Plantas Úteis do Brasil. Ministério da Agricultura, Brasília, DF, Brasil.
  • 3 Muir CK & Lam CK (1980). Depressant action of Averrhoa carambola. Medical Journal of Malaysia, 34: 279-280.
  • 4 Martha RCD, Poubel J, Ferreira LCL, Lima RS, Borrás MR, Costa PRC & Roland IA (2000). Atividade hipoglicêmica de Averrhoa carambola L. usada em Manaus como antidiabético. NewsLab, 38: 142-148.
  • 5 Padmawinata K & Hoyaranda E (1980). The effect of the juice of Averrhoa carambola fruit and the aqueous extract of Persia Americana leaves on rat blood pressure. 4th Asian Symposium on Medicinal Plants and Spices, Bangkok, Thailand, 159 (Abstract).
  • 6 Neto MM, Costa JA, Garcia-Cairasco N, Netto JC, Nakagawa B & Dantas M (2003). Intoxication by star fruit (Averrhoa carambola) in 32 uremic patients: treatment and outcome. Nephrology, Dialysis, Transplantation, 18: 120-125.
  • 7 Tse K-C, Yip P-S, Lam M-F, Choy B-Y, Li F-K, Lui S-L, Lo W-K, Chan T-M & Lai K-N (2003). Star fruit intoxication in uremic patients: case series and review of the literature. Internal Medicine Journal, 33: 314-316.
  • 8 Cooke T, The Flora of the Presidency of Bombay, Botanical Survey of India,1961;1: Calcutta.
  • 9 Flora: A Gardener's Encyclopedia: 2004; 1: Garden Cheers Publishing.
  • 10 Kirtikar K.R. and Basu. B.D.: Indian Medicinal Plants: 1989;1: 2nd Edition . Published by Lalit Mohan Basu Allahabad, India.
  • 11 Parrotta J.A. Healing Plants of Peninsular India, 2001;CABI Publishing, USA.
  • 12 Md. Masum Mia, Mohmad S. Rahman, Kohinur Begum, Bilkis Begum and Mohammad A. Rashid: J.Pharm. Sci. 2007; 6(2): 125-128.
  • 13 Chung K S, Paul P H, Kimura T. International Collation of Traditional and folk medicine: Northeast Asia.1998:75.
  • 14 Hayes WB. Fruits growing in India. Allahabad: Kitabistan; 1960.
  • 15 Campbell CW, Knight RJ, Olszack R., Carambola production in Florida. Proc. Fla. State Hort. Soc. 1985; 98:145- 149.
  • 16 Campbell CW. Tropical fruit crops in Florida: A rapidly changing situation. Proc. Fla. Sate Hort. Soc. 1986; 99:217-219.
  • 17 Morton J. Carambola. In: Fruits of warm climates. Julia F. Morton, Miami, FL; 1987. p. 125-128. (17)
  • 18 Sheth A. The Herbs of Ayurveda. Ashok K. Sheth, publisher; 2005. Vol 1 p. 140. (18)
  • 19 Kirtikar KR, Basu BD. Indian Medicinal Plants. Vol. 1. Second Edition. Published by Lalit Mohan Basu; 1984.
  • 20 Wealth of India: A Dictionary of Indian Raw Materials and Industrial Products. Delhi: Council of Scientific and Industrial Research; 1948.
  • 21 Kirtikar KR, Basu BD. Indian Medicinal Plants. Vol. 1. Second Edition. Published by Lalit Mohan Basu; 1984.
  • 22 Martha RCD, Poubel J, Ferreira LCL, Lima RS, Borrás MR, Costa PRC, Roland IA. Atividade hipoglicêmicade Averrhoa carambola L. usada em Manaus como antidiabético. NewsLab. 2000; 38:142-148.
  • 23 Ferreira EB, Fernandes LC, Galende SB, Cortez DAG, Bazotte RB. Hypoglycemic effect of the hydroalcoholic extract of leaves of Averrhoa carambola L. (Oxalidaceae). Brazilian Journal of Pharmacognosy. 2008; 18(3):339-343.
  • 24 Vasconcelos CML, Araujo MS, Silva BA, Conde-Garcia EA. Negative inotropic and chronotropic effects on the guinea pig atrium of extracts obtained from Averrhoa carambola L. leaves. Braz. J. Med. Biol. Res. 2005; 38(7):1113-1122.
  • 25 Cabrini DA, Moresco HH, Imazu P, Delai da Silva C, Pietrovski EF, Gasparin DA, Mendes B, Prudente A, Pizzolatti MG, Brighente IMC, Otuki MF. Analysis of the Potential Topical Anti-Inflammatory Activity of Averrhoa carambola L. in Mice. Hindawi Publishing Corporation. Evidence-Based Complementary and Alternative Medicine. 2010; Volume 2011, Article ID 908059, 7 pages doi:10.1093/ecam/neq
  • 26 Thomas S, Patil DA, Patil AG, Naresh Chandra. Pharmacognostic evaluationand physicochemical analysis of Averrhoa carambola L. fruit. Journal of Herbal Medicine and Toxicology. 2008; 2(2):51-54.
  • 27 Neto MM, Robl F & Netto JC (1998). Intoxication by star fruit (Averrhoa carambola) in six dialysis patients. Nephrology, Dialysis, Transplantation, 13: 570-572.
  • 28 Chang J-M, Hwang S-J, Kuo H-T, Tsai J-C, Guh JY, Chen H-C, Tsai J-H & Lai Y-H (2000). Fatal outcome after ingestion of star fruit (Averrhoa carambola) in uremic patients. American Journal of Kidney Diseases, 35: 189-193.
  • 29 Chang CT, Chen YC, Fang JT & Huang CC (2002). Star fruit (Averrhoa carambola) intoxication: an important cause of consciousness disturbance in patients with renal failure. Renal Failure, 24: 379-382.
  • 30 Cecchini AL, Fontana ACK, Beleboni RO, Pizzo AB, Santos WF, Thomazini JA, Neto MM & Coutinho-Netto J (1999). Purification and biochemical characterization of a convulsant neurotoxin from the star fruit (Averrhoa carambola): specific neurotransmitter release on rat cerebral cortex synaptosomes. Presented at the XIV Annual Meeting of the Federação de Sociedades de Biologia Experimental, Caxambu, MG, Brazil, August 25-28, Abstract 12.193.
  • 31 Halliwell B, Gutteridge JM. Free radicals in biology and medicine Oxford: Oxford University Press; 1998.
  • 32 Yazdanparast R, Ardestani A. In vitro antioxidant and free radical scavenging activity of Cyperus rotundus. J Med Food 2007; 10: 667- 674.
  • 33 Yazdanparast R, Bahramikias S, Ardestani A: Nasturtium oficinale reduces oxidative stress and enhances antioxidant capacity in hypercholesterolaemic rats. Chem Biol Interact 2008; 172:176-184.
  • 34 P. Varadarajan, G. Rathinaswamy, and D. Asirvatahm. Antimicrobial properties and phytochemical constituents of Rheo discolor. Ethnobotanical Leaflet.2008; 12: 841–845.
  • 35 L, Ong ASH. Biological oxidants and antioxidants: Molecular mechanisms and health effects Champaign, 1997; IL: AOCS Press.
  • 36 Jovanovic SV, Simic MG: Antioxidants in nutrition. Ann NY Acad Sci 2000; 899: 326-334.
  • 37 Arnao M.B, Cano and M.Acosta..The hydrophilic and lipophilic contribution to total antioxidant activity, Food Chem, 2001; 73: 239- 244.