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CC BY-NC-ND 4.0 · Journal of Health and Allied Sciences NU 2014; 04(02): 070-080
DOI: 10.1055/s-0040-1703767
Original Article

EVALUATION OF RADIO PROTECTIVE EFFECT OF AVERRHOA CARAMBOLA LEAVES EXTRACT IN WISTAR RATS

Arunachalam Kumar
1   Professor & Head, Department of Anatomy, K.S. Hegde Medical Academy, Nitte University Mangalore - 575 018, Karnataka, India
,
Suchetha Kumari N.
2   Department of Biochemistry, Professor, K.S. Hegde Medical Academy, Nitte University Mangalore - 575 018, Karnataka, India
,
Kavitha K.
3   Lecturer, Department of Anatomy, K.S. Hegde Medical Academy, Nitte University Mangalore - 575 018, Karnataka, India
,
Rojin T. S.
4   Lecturer, Department of Pharmacology, K.S. Hegde Medical Academy, Nitte University Mangalore - 575 018, Karnataka, India
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Abstract:

The present study was designed to investigate the radio protective efficacy of ethanolic extract of leaves of the Averrhoa carambola by studying the following parameters: radioprotective effect before and after radiation, estimating the Total Antioxidant Status, haematological parameters, assessing the histopathology of liver and kidney. Extract was given orally at a dose of 450 mg/kg, orally for 15 days prior to and 15 days after radiation (2 Gy). The rats were kept under observation for 15 days for any sign of radiation sickness, morbidity, behavioural toxicity, urination and defecation pattern or mortality, which showed no changes. The haematological parameters showed a significant decrease in the irradiated rat when compared with the control group. Antioxidant activity revealed from the data obtained in the present study showed that A.carambola leaves ethanolic extract possess good antioxidant activity. Histopathological changes in the irradiated liver and kidney sections showed improved cellular architecture when compared to the normal. The present study suggests that supplementation with Averrhoa carambola has potent antioxidant activity and act as probable radioprotector against gamma radiation induced oxidative damage.

Keywords:

Averrhoa carambola - radioprotection - Gamma-radiation - oxidative damage


Publication History

Article published online:
24 April 2020

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