Semin Neurol 2020; 40(03): 322-334
DOI: 10.1055/s-0040-1702939
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Predictors of Long-Term Neurodevelopmental Outcome of Hypoxic-Ischemic Encephalopathy Treated with Therapeutic Hypothermia

Ipsita Goswami*
1  Department of Paediatrics, Hospital for Sick Children, Toronto, Canada
2  Department of Paediatrics, University of Toronto, Toronto, Canada
,
Mireille Guillot*
1  Department of Paediatrics, Hospital for Sick Children, Toronto, Canada
2  Department of Paediatrics, University of Toronto, Toronto, Canada
,
Emily W. Y. Tam
1  Department of Paediatrics, Hospital for Sick Children, Toronto, Canada
2  Department of Paediatrics, University of Toronto, Toronto, Canada
› Author Affiliations
Further Information

Publication History

Publication Date:
20 February 2020 (online)

Abstract

Hypoxic-ischemic encephalopathy (HIE) is a manifestation of perinatal asphyxial insult that continues to evolve over days to weeks following the initial injury. Therapeutic hypothermia has demonstrated that a proportion of this secondary brain injury may indeed be preventable. However, therapeutic hypothermia has also altered the prognostic utility of many bedside tools that are commonly used as predictors of long-term neurodevelopmental outcome in HIE. Clinicians are often confronted with uncertainty when assessing the prognosis of infants with HIE. Improved understanding of the implications and limitations of individual investigations may inform clinical decisions and allow for timely intervention. This review summarizes the predictive value of currently available prognostic markers in HIE infants in the therapeutic hypothermia era, including clinical, biochemical, neurophysiological, physiological, and neuroimaging predictors.

* Both these authors contributed equally to the manuscript.