Computed Tomography as a Predictor of Sinonasal Inverted Papilloma Origin, Skull Base Involvement, and Stage

Jake J. Lee; Hilary L. P. Orlowski; John S. Schneider; Lauren T. Roland; Rami Eldaya; Pawina Jiramongkolchai; Dorina Kallogjeri; Rebecca D. Chernock; Cristine N. Klatt-Cromwell

doi:10.1055/s-0040-1701677

Journal of Neurological Surgery Part B: Skull Base, Table of Contents

J Neurol Surg B Skull Base 2021; 82(S 03): e335-e341
DOI: 10.1055/s-0040-1701677

Original Article

Computed Tomography as a Predictor of Sinonasal Inverted Papilloma Origin, Skull Base Involvement, and Stage

Jake J. Lee

¹Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, Missouri, United States

,

Hilary L. P. Orlowski

²Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, United States

,

John S. Schneider

¹Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, Missouri, United States

,

Lauren T. Roland

¹Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, Missouri, United States

³Department of Otolaryngology-Head and Neck Surgery, Emory University School of Medicine, Atlanta, Georgia, United States

⁵Department of Otolaryngology-Head and Neck Surgery, San Francisco School of Medicine, University of California, San Francisco, California, United States

,

Rami Eldaya

²Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, United States

,

Pawina Jiramongkolchai

¹Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, Missouri, United States

,

Dorina Kallogjeri

¹Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, Missouri, United States

,

Rebecca D. Chernock

⁴Department of Pathology, Washington University School of Medicine, St. Louis, Missouri, United States

,

Cristine N. Klatt-Cromwell

¹Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, Missouri, United States

› Author Affiliations

Abstract

Objective To investigate the diagnostic performance of computed tomography (CT) to determine the origin, skull base involvement, and stage of sinonasal inverted papilloma (IP).

Design This is a retrospective cohort study.

Setting This is set at a tertiary care medical center.

Participants Patients with preoperative CT imaging who underwent extirpative surgery for histologically confirmed sinonasal IP between January 2005 and October 2019.

Main Outcome Measures The likely sites of tumor origin, skull base involvement, and radiographic tumor stage were determined by two board-certified neuroradiologists after re-reviewing preoperative CT imaging. These radiologic findings were then compared with intraoperative and pathologic findings.

Results Of 86 patients, 74% (64/86) had IP lesions with correctly classified sites of origin on CT. CT was not sensitive for diagnosing ethmoid sinus origin (48%, 52%), frontal sinus origin (80%, 40%), and skull base origin (17%, 17%). CT was not sensitive (62%, 57%) but specific (86%, 98%) for identifying any skull base involvement. There was substantial-to-near perfect agreement between radiographic and pathologic Cannady stages (weighted κ = 0.61 for rater 1; weighted κ = 0.81 for rater 2). Interrater agreement was substantial for identifying tumor origin (κ = 0.75) and stage (weighted κ = 0.62) and moderate for identifying skull base involvement (κ = 0.43).

Conclusion Interrater agreement on CT findings was substantial except on skull base involvement. CT correctly predicted site of tumor origin in up to 74% of subjects. CT was not sensitive for diagnosing skull base involvement but had substantial-to-near perfect agreement with pathologic tumor staging. CT is a useful but albeit limited adjunct for tumor localization and surgical planning for sinonasal IP.

Keywords

inverted papilloma - paranasal sinus - origin - skull base - stage - computed tomography

Full Text

References

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