Int J Angiol 2020; 29(01): 002-011
DOI: 10.1055/s-0040-1701639
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Triglycerides and Cardiovascular Outcomes—Can We REDUCE-IT ?

1  Department of Cardiology, King George's Medical University, Lucknow, Uttar Pradesh, India
,
Monika Bhandari
1  Department of Cardiology, King George's Medical University, Lucknow, Uttar Pradesh, India
,
Pravesh Vishwakarma
1  Department of Cardiology, King George's Medical University, Lucknow, Uttar Pradesh, India
,
Rishi Sethi
1  Department of Cardiology, King George's Medical University, Lucknow, Uttar Pradesh, India
› Author Affiliations
Further Information

Publication History

Publication Date:
25 February 2020 (online)

Abstract

The causal linkage between triglycerides and coronary artery disease has been controversial. Most of the trials hitherto have shown marginal or no beneficial effects of reduction of triglycerides (with fibrates) on top of low-density lipoprotein (LDL) reduction. But a significant residual cardiovascular risk remains even after use of high dose of statins. Omega-3 fatty acids have been shown to reduce triglyceride levels and some old trials have shown the benefits of fish oils in reducing cardiovascular events. However, barring a few trials most of the large trials of omega-3 fatty acids are negative. Recently, few large trials have been conducted to see the effects of high dose omega-3 fatty acids on cardiovascular outcomes and some of them have shown promising results on top of LDL reduction.