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CC BY 4.0 · Pharmaceutical Fronts 2020; 02(01): e11-e22
DOI: 10.1055/s-0040-1701435
Review Article
Georg Thieme Verlag KG Stuttgart · New York

Current Advances in Sustained Release Microneedles

Guangsheng Du
1   Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, PR China
,
Xun Sun
1   Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, PR China
› Author Affiliations Funding We acknowledge the financial support of the National Natural Science Foundation of China (No. 81961130395), Science and Technology Major Project of Sichuan Province (No. 2018SZDZX0018), and Sichuan Veterinary Medicine and Drug Innovation Group of China Agricultural Research System (CARS-SVDIP).
Further Information

Publication History

14 November 2019

04 December 2019

Publication Date:
25 February 2020 (online)

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Abstract

Microneedles have been extensively investigated for intradermal delivery of drugs and vaccines due to advantages including high skin delivery efficiency, improved patient compliance, and potential for self-administration. However, traditional microneedles cannot regulate the release kinetics of payloads, limiting therapeutic utility of the biotherapeutics. Recently, several types of microneedles with sustained release properties, including slow-dissolving microneedles made of hydrophilic polymers, degradable microneedles made of hydrophobic polymers, and bioresponsive microneedles made of bioresponsive polymers, have been developed and investigated for intradermal delivery of the biotherapeutics, aiming for improving their therapeutic potency, reducing side effects and administration frequency, and further improving patient compliance. In this review, we introduced different types of microneedles that have been designed for sustained release of the payloads, summarized various applications of these microneedles, and discussed the future prospects of this technology.

Keywords

sustained release - polymeric microneedles - drug delivery - vaccines
 

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