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CC BY-NC-ND 4.0 · Revista Urología Colombiana / Colombian Urology Journal 2020; 29(04): 240-244
DOI: 10.1055/s-0040-1701278
Review Article | Artículo de Revisión
General Urology/Urología General

Mecanismos inflamatorios involucrados en la fisiopatología de la hiperplasia prostática benigna

Inflammatory Mechanisms Involved in the Pathophysiology of Benign Prostatic Hyperplasia
Ximena Guzman Robledo
1   Universidad del Valle, Cali, Colombia
,
Herney Andrés García-Perdomo 
2   Escuela de Medicina, Grupo de Investigación UROGIV, Universidad del Valle, Cali, Colombia
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Resumen

La obstrucción del tracto de salida ha sido asociada con la hiperplasia prostática benigna (HPB), dado el crecimiento progresivo del adenoma, lo cual lleva a un incremento en la resistencia al flujo urinario, junto con un efecto deletéreo en la función renal. Se han descrito múltiples teorías asociadas con el desarrollo de la hiperplasia. Entre las cuales se encuentran: La edad, el incremento en la actividad simpática, alteraciones hormonales, el síndrome metabólico y la inflamación crónica. En los últimos años, el rol de la inflamación prostática local en el entendimiento de la patogénesis y progresión de la HPB ha cobrado relevancia. Esa hipótesis plantea que infiltrados inflamatorios conllevan a una lesión tisular, generando así un proceso crónico de cicatrización que condiciona el incremento en el tamaño prostático. El presente artículo se enfoca en describir los mecanismos inflamatorios involucrados en la fisiopatología de la hiperplasia prostática benigna.

Abstract

Urinary tract obstruction has been associated with benign prostatic hyperplasia (BPH), given the progressive adenoma growth. This process leads to an increase in urinary flow resistance, associated with a deleterious effect of renal function. Age, increased sympathetic activity, hormonal alterations, metabolic syndrome and chronic inflammation are among the multiple theories associated with the development of hyperplasia. In recent years, the role of local prostatic inflammation in understanding the pathogenesis and progression of BPH has become relevant. This hypothesis suggests that inflammatory infiltrates lead to a tissue injury, thus generating a chronic healing process that conditions the prostatic increase. The present article focuses on describing the inflammatory mechanisms involved on BPH pathophysiology.

Palabras Clave

hiperplasia prostática benigna - obstrucción del tracto de salida - inflamación crónica

Keywords

benign prostatic hyperplasia - obstruction of the outflow tract - chronic inflammation


Publication History

Received: 19 April 2019

Accepted: 02 December 2019

Article published online:
11 March 2020

© 2020. Sociedad Colombiana de Urología. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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