Abstract
Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a primary liver tumor with
neoplastic components of both hepatocytic and cholangiocytic differentiation. This
unique neoplasm is gaining increasing recognition due to the intriguing pathology,
tumor biology, and clinical behavior. It also poses challenges in diagnosis, treatment,
and research, largely because of its histological and phenotypic diversity that lead
to confusion in terminology and classification. There have been efforts attempting
to unify the terminology of this neoplasm recently. Advances in investigation in various
aspects have also been made. This review aims to update the terminology, classification,
and clinical and pathological characteristics of cHCC-CCA.
Keywords
combined hepatocellular carcinoma-cholangiocarcinoma - hepatocytic - cholangiocytic
