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Semin Liver Dis 2020; 40(02): 124-130
DOI: 10.1055/s-0039-3402515
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

A Review on the Update of Combined Hepatocellular Cholangiocarcinoma

Mina Komuta
1   Department of Pathology, Cliniques Universitaires Saint-Luc/Université Catholique de Louvain, Brussels, Belgium
,
Matthew M. Yeh
2   Department of Pathology, University of Washington School of Medicine, Seattle
3   Department of Medicine, University of Washington School of Medicine, Seattle
› Author Affiliations Funding Sources None to disclose.
Further Information

Publication History

Publication Date:
30 December 2019 (online)

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Abstract

Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a primary liver tumor with neoplastic components of both hepatocytic and cholangiocytic differentiation. This unique neoplasm is gaining increasing recognition due to the intriguing pathology, tumor biology, and clinical behavior. It also poses challenges in diagnosis, treatment, and research, largely because of its histological and phenotypic diversity that lead to confusion in terminology and classification. There have been efforts attempting to unify the terminology of this neoplasm recently. Advances in investigation in various aspects have also been made. This review aims to update the terminology, classification, and clinical and pathological characteristics of cHCC-CCA.

Keywords

combined hepatocellular carcinoma-cholangiocarcinoma - hepatocytic - cholangiocytic
 

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