Tierarztl Prax Ausg K Kleintiere Heimtiere 2020; 48(01): 64-65
DOI: 10.1055/s-0039-3402395
Abstracts
DVG
© Georg Thieme Verlag KG Stuttgart · New York

Neoadjuvant therapy of locally advanced feline injection site sarcoma with thermosensitive doxorubicin-containing phosphatidyldiglycerol liposomes or free doxorubicin in combination with regional hyperthermia

K. Troedson
1  Clinic of Small Animal Medicine at the Centre for Clinical Veterinary Medicine, LMU Munich,, Munich, Germany
,
M. Hossann
2  Thermosome GmbH,, Planegg/Martinsried, Munich, Germany
3  Department of Internal Medicine III, University Hospital of Munich, LMU Munich,, Munich, Germany
,
J. Hirschberger
1  Clinic of Small Animal Medicine at the Centre for Clinical Veterinary Medicine, LMU Munich,, Munich, Germany
,
C. Ratzlaff
1  Clinic of Small Animal Medicine at the Centre for Clinical Veterinary Medicine, LMU Munich,, Munich, Germany
,
S. Baer
1  Clinic of Small Animal Medicine at the Centre for Clinical Veterinary Medicine, LMU Munich,, Munich, Germany
,
A. Meyer-Lindenberg
4  Clinic of Small Animal Surgery and Reproduction at the Centre for Clinical Veterinary Medicine, LMU Munich,, Munich, Germany
,
K. Winger
5  Tierklinik am Hasenberg,, Stuttgart, Germany
,
G. Wess
1  Clinic of Small Animal Medicine at the Centre for Clinical Veterinary Medicine, LMU Munich,, Munich, Germany
,
R. Doerfelt
1  Clinic of Small Animal Medicine at the Centre for Clinical Veterinary Medicine, LMU Munich,, Munich, Germany
,
M. Schweiger
6  Department of Nuclear Medicine, University Hospital rechts der Isar, TUM Munich,, Munich, Germany
,
C. Baumgartner
6  Department of Nuclear Medicine, University Hospital rechts der Isar, TUM Munich,, Munich, Germany
,
M. Peller
7  Department of Radiology, University Hospital Munich, LMU Munich,, Munich, Germany
,
L. Lindner
3  Department of Internal Medicine III, University Hospital of Munich, LMU Munich,, Munich, Germany
› Author Affiliations
Further Information

Publication History

Publication Date:
17 February 2020 (online)

 

Background Feline injection-site sarcoma (FISS) is a locally advance tumor that requires a multimodality therapy. FISS shows a low response to doxorubicin (DOX). This could be improved with DOX-loaded phosphatidyldiglycerol-based thermosensitive liposomes (DPPG2-TSLs) and regional hyperthermia (RHT).

Hypothesis/objectives DPPG2-TSL-DOX and RHT leads to improved treatment response than DOX and RHT.

Animals Eight cats were included; 4 cats were treated with 1 mg/kg DPPG2-TSL-DOX and 4 cats were treated with 1 mg/kg DOX, both in combination with RHT.

Methods After complete staging including PET-MRI, 6 treatment cycles with DPPG2-TSL-DOX or DOX in combination with RHT were applied q 2 weeks. Treatment response was monitored via calliper and PET-MRI measurements. RHT with a target temperature of 41.5°C was started 15 minutes before i. v. drug administration and continued for a total of 60 minutes.

Results Treatment was feasible and no dose-limiting toxicity was observed. All cats treated with DPPG2-TSL-DOX showed a response to treatment whereas only one cat treated with free DOX responded to treatment.

Conclusions The neoadjuvant treatment with DPPG2-TSL-DOX and RHT was well tolerated and effective. Response to treatment with DPPG2-TSL-DOX suggests overcoming drug resistance mechanism by a more effective drug delivery. This treatment combination exhibits a great potential for the treatment of advanced stage FISS.