Inflammatory Myofibroblastic Tumor of Spinal Canal: Brief Case Report

Abstract

We describe a case of an intradural extramedullary inflammatory myofibroblastic tumor of the cervical spine. A 56-year-old woman presented with progressive neck pain, radiating to the right scapula, without any neurologic deficit. Magnetic resonance imaging showed an intradural extramedullary tumor with a dural tail sign, located at the C3–T1 segment with homogeneous contrast enhancement. The patient was operated on for a suspected meningioma. Pathologic examination showed fibrosis and inflammation with infiltration of B and T lymphocytes accompanied by plasmocytes, macrophages, and myofibroblast oocytes. We present the clinical course and review of the literature.

Keywords

inflammatory myofibroblastic tumor - spine tumor - meningioma - lymphoma

• References

• 1 Louis DN, Perry A, Reifenberger G. , et al. The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathol 2016; 131 (06) 803-820
• 2 Zemmoura I, Hamlat A, Morandi X. Intradural extramedullary spinal inflammatory myofibroblastic tumor: case report and literature review. Eur Spine J 2011; 20 (Suppl. 02) S330-S335
• 3 Wang S, Chen L, Cao Z, Mao X, Zhang L, Wang B. Inflammatory myofibroblastic tumor of the lumbar spinal canal: a case report with literature review. Medicine (Baltimore) 2017; 96 (26) e6488
• 4 Seider MJ, Cleary KR, van Tassel P. , et al. Plasma cell granuloma of the nasal cavity treated by radiation therapy. Cancer 1991; 67 (04) 929-932
• 5 Kutok JL, Pinkus GS, Dorfman DM, Fletcher CD. Inflammatory pseudotumor of lymph node and spleen: an entity biologically distinct from inflammatory myofibroblastic tumor. Hum Pathol 2001; 32 (12) 1382-1387
• 6 Boutarbouch M, Arkha Y, Rifi L, Derraz S, El Ouahabi A, El Khamlichi A. Intradural cervical inflammatory pseudotumor mimicking epidural hematoma in a pregnant woman: case report and review of the literature. Surg Neurol 2008; 69 (03) 302-305
• 7 Hytiroglou P, Brandwein MS, Strauchen JA, Mirante JP, Urken ML, Biller HF. Inflammatory pseudotumor of the parapharyngeal space: case report and review of the literature. Head Neck 1992; 14 (03) 230-234
• 8 Karatsis P, Wyman A, Sweetland HM, Bull AD, Rogers K. Inflammatory pseudotumour of the liver. Eur J Surg Oncol 1993; 19 (04) 384-387
• 9 Gómez-Román JJ, Sánchez-Velasco P, Ocejo-Vinyals G, Hernández-Nieto E, Leyva-Cobián F, Val-Bernal JF. Human herpesvirus-8 genes are expressed in pulmonary inflammatory myofibroblastic tumor (inflammatory pseudotumor). Am J Surg Pathol 2001; 25 (05) 624-629
• 10 Arber DA, Kamel OW, van de Rijn M. , et al. Frequent presence of the Epstein-Barr virus in inflammatory pseudotumor. Hum Pathol 1995; 26 (10) 1093-1098
• 11 Coffin CM, Watterson J, Priest JR, Dehner LP. Extrapulmonary inflammatory myofibroblastic tumor (inflammatory pseudotumor). A clinicopathologic and immunohistochemical study of 84 cases. Am J Surg Pathol 1995; 19 (08) 859-872
• 12 De Vuysere S, Hermans R, Sciot R, Crevits I, Marchal G. Extraorbital inflammatory pseudotumor of the head and neck: CT and MR findings in three patients. AJNR Am J Neuroradiol 1999; 20 (06) 1133-1139
• 13 Jeon YK, Chang KH, Suh YL, Jung HW, Park SH. Inflammatory myofibroblastic tumor of the central nervous system: clinicopathologic analysis of 10 cases. J Neuropathol Exp Neurol 2005; 64 (03) 254-259
• 14 Despeyroux-Ewers M, Catalaâ I, Collin L, Cognard C, Loubes-Lacroix F, Manelfe C. Inflammatory myofibroblastic tumour of the spinal cord: case report and review of the literature. Neuroradiology 2003; 45 (11) 812-817
• 15 Albizzati C, Ramesar KC, Davis BC. Plasma cell granuloma of the larynx (case report and review of the literature). J Laryngol Otol 1988; 102 (02) 187-189
• 16 Pettinato G, Manivel JC, Insabato L, De Chiara A, Petrella G. Plasma cell granuloma (inflammatory pseudotumor) of the breast. Am J Clin Pathol 1988; 90 (05) 627-632
• 17 Warter A, Satge D, Roeslin N. Angioinvasive plasma cell granulomas of the lung. Cancer 1987; 59 (03) 435-443
• 18 Eimoto T, Yanaka M, Kurosawa M, Ikeya F. Plasma cell granuloma (inflammatory pseudotumor) of the spinal cord meninges: report of a case. Cancer 1978; 41 (05) 1929-1936
• 19 Mirra SS, Tindall SC, Check IJ, Brynes RK, Moore WW. Inflammatory meningeal masses of unexplained origin. An ultrastructural and immunological study. J Neuropathol Exp Neurol 1983; 42 (04) 453-468
• 20 Satomi F, Mori H, Ogasawara H, Kumoi T, Uematsu K. Subglottic plasma cell granuloma: report of a case. Auris Nasus Larynx 1991; 18 (04) 391-399
• 21 Yoshimura K, Sasaki M, Kojima M. , et al. Spontaneous regression of inflammatory pseudotumor in the cauda equina: a case report. NMC Case Rep J 2016; 3 (04) 111-114
• 22 Hsiang J, Moorhouse D, Barba D. Multiple plasma cell granulomas of the central nervous system: case report. Neurosurgery 1994; 35 (04) 744-747
• 23 Hsieh PC, Lin CN. Multicentric plasma cell granuloma of spinal cord meninges. Clin Orthop Relat Res 1995; (317) 188-192
• 24 Lacoste-Collin L, Roux FE, Gomez-Brouchet A. , et al. Inflammatory myofibroblastic tumor: a spinal case with aggressive clinical course and ALK overexpression. Case report. J Neurosurg 2003; 98 (2, Suppl): 218-221
• 25 Brandsma D, Jansen GH, Spliet W, Van Nielen K, Taphoorn MJ. The diagnostic difficulties of meningeal and intracerebral plasma cell granulomas—presentation of three cases. J Neurol 2003; 250 (11) 1302-1306
• 26 Yoon SH, Kim KJ, Chung SK. , et al. Inflammatory myfibroblastic tumor in the intradural extramedullary space of the lumbar spine with spondylolisthesis: case report and review of the literature. Eur Spine J 2010; 19 (Suppl. 02) S153-S157
• 27 Schöffski P, Sufliarsky J, Gelderblom H. , et al. Crizotinib in patients with advanced, inoperable inflammatory myofibroblastic tumours with and without anaplastic lymphoma kinase gene alterations (European Organisation for Research and Treatment of Cancer 90101 CREATE): a multicentre, single-drug, prospective, non-randomised phase 2 trial. Lancet Respir Med 2018; 6 (06) 431-441