Planta Med 2019; 85(18): 1556
DOI: 10.1055/s-0039-3400117
Main Congress Poster
Poster Session 2
© Georg Thieme Verlag KG Stuttgart · New York

A multicenter, prospective, pharmacy-based cohort study with a combination of essential oils from peppermint and caraway in functional gastrointestinal disorders

S Noé
1   Bären-Apotheke,, Karlsruher Str. 26, 76139 Karlsruhe-Hagsfeld, Germany
,
FA Malek
2   Clinical Research Department, Dr. Willmar Schwabe GmbH & Co. KG,, Willmar-Schwabe-Str.4, 76227 Karlsruhe, Germany
,
B Stracke
2   Clinical Research Department, Dr. Willmar Schwabe GmbH & Co. KG,, Willmar-Schwabe-Str.4, 76227 Karlsruhe, Germany
,
A Madisch
3   Medical Department I, Academic Teaching Hospital Siloah,, Stadionbrücke 4, 30459 Hannover, Germany
› Author Affiliations
Further Information

Publication History

Publication Date:
20 December 2019 (online)

 

Functional gastrointestinal disorders (FGID) are defined by lack of organic cause with interindividual differences in symptom emergence and severity. Functional dyspepsia (FD) and irritable bowel syndrome (IBS) belong to the most prevalent FGIDs.

The present pharmacy-based cohort study aimed at gaining insights into effects and tolerability of Menthacarina - a proprietary specified combination of essential oils from Mentha x piperita L. (90 mg WS® 1340) and Carum carvi L. (50 mg WS® 1520) - applied in subjects suffering from FGID, particularly with mild cramps, bloating and/or fullness. Occurrence and severity of 13 dyspeptic symptoms were assessed at the beginning and during 3 weeks of Menthacarin intake using a modified Gastrointestinal Symptoms Rating Scale (GSRS) [1]. Also, patient satisfaction and tolerability were evaluated by pharmacists and pharmacy customers.

50 participants (mean age 54 years) were recruited. After 3 weeks, the GSRS total score was reduced from 48.6±17.1 to 22.8±12.3 points (p<0.001). 44.9% of the patients rated the perceived effects as “very good” or “good” and 30.6% as “satisfactory”, which was comparable to the pharmacists’ rating. 83.3% of the pharmacy customers´ and 87.7% of the pharmacists´ ratings for tolerability of Menthacarin were “very good” or “good”.

These findings clearly indicate the safety and the good applicability of Menthacarin in pharmacy-supported self-medication of patients suffering from FGID.

aMenthacarin® is the active agent of the product Carmenthin® bei Verdauungsstörungen (Dr. Willmar Schwabe GmbH & Co. KG, Karlsruhe).

 

  • References

  • 1 Svedlund J, Sjödin I, Dotevall G. GSRS–a clinical rating scale for gastrointestinal symptoms in patients with irritable bowel syndrome and peptic ulcer disease. Dig Dis Sci 1998; 33: 129-134
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