Effects of Oroxylum indicum (L.) Kurz extract on lipid profile of high fat diet-induced mice

Oroxylum indicum has been known as traditional herbal medicine, its widely found in Asian countries [1]. Our previous study showed that the fruits of O. indicum extract (OIE) were remarkably reduced the lipid accumulation in 3T3-L1 adipocytes (In vitro) [2]. This study was aimed to assess the effect of the OIE on the lipid level in high fat diet-induced mice. Forty-eight of male mice were divided into 6 groups; (1) Normal control (NC); (2) High fat diet (HFD); (3) High fat diet treated with 25 mg/kg/day simvastatin (positive control); (4) High fat diet treated with 100, 200, and 300 mg/kg/day of OIE, respectively. At the end of the experiment (4 weeks), mice were fasted overnight, and blood samples were collected to measure total serum cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL), and high-density lipoprotein (HDL). During the study, food intake, body weight, and toxicity signs were measured. The results demonstrated that OIE did not show any visible signs of toxicity. Food intake and body weight were also no significant difference between HFD and OIE treated group (P < 0.05). The TC and TG of OIE treated groups were significantly lower than the HFD group in a dose-dependent manner (P < 0.05), while LDL and HDL levels showed no significantly different. In conclusion, the OIE has potential on decreased of lipid profiles in hyperlipidemic mice. Thus, it could be a benefit for further long term investigation to prevent hyperlipidemia.

Fig.1

• References

• 1 Harminder Singh V, Chaudhary AK. A review on the taxonomy, ethnobotany, chemistry and pharmacology of Oroxylum indicum vent. Indian J Pharm Sci 2011; 73: 483-490
• 2 Hengpratom T, Lowe GM, Thumanu K, Suknasang S, Tiamyom K, Eumkreb G. Oroxylum indicum (L.) Kurz extract inhibits adipogenesis and lipase activity in vitro. BMC Complement Altern Med 2018; 18: 177-177