Planta Med 2019; 85(18): 1516-1517
DOI: 10.1055/s-0039-3399968
Main Congress Poster
Poster Session 2
© Georg Thieme Verlag KG Stuttgart · New York

Benzoxazinoids in human diet: an anti-cancer agent?

B Bhattarai
1   Aarhus University,, Department of Agroecology, Forsøgsvej 1, 4200 Slagelse, Denmark
,
SK Steffensen
1   Aarhus University,, Department of Agroecology, Forsøgsvej 1, 4200 Slagelse, Denmark
,
PL Gregersen
2   Aarhus University,, Department of Molecular Biology and Genetics, 4200 Slagelse, Denmark
,
JH Jensen
3   Aarhus University,, Department of Clinical medicine, Palle Juul-Jensens Boulevard 99, 8200 Aarhus, Denmark
,
KD Sørensen
3   Aarhus University,, Department of Clinical medicine, Palle Juul-Jensens Boulevard 99, 8200 Aarhus, Denmark
,
MT Skaanild
4   Skaanild & Partners ApS,, Juelsminde, Denmark
,
IS Fomsgaard
1   Aarhus University,, Department of Agroecology, Forsøgsvej 1, 4200 Slagelse, Denmark
› Author Affiliations
Further Information

Publication History

Publication Date:
20 December 2019 (online)

 

Benzoxazinoids (BXs) are phytochemicals present in selected cereal crops and medicinal plants. Effects of BXs as plant defense and allelopathic agents have been widely studied [1],[2], while the knowledge on effects in mammals is limited. Potential therapeutic effects of BXs in humans [3], and presence of BXs in prostate cancer tissue in prostate cancer patients fed with a diet of rye, which was rich in BXs, [4], motivated us towards exploring the effects of BXs in prostate cancer cells.

The effects were studied by exposing prostate cancer cell lines LNCap, DU145, PC3, and C4, and primary prostate cancer cells to selected BXs. Agluconic forms of BXs, which were reported to be the most active form of the compounds, were tested. DIBOA (2,4-dihydroxy-1,4-benzoxazin-3-one) and DIMBOA (2,4-dihydroxy-7-methoxy-1,4-benzoxazin-3-one) caused a decrease in cell viability across all the cell lines tested. The IC50 of the compounds ranged from 40 to 200 µM across different cell lines. The results are encouraging and further experiments will be carried out using RNA sequencing. The ultimate goal is to understand the mechanism behind the potential anti-cancer effect of BXs and to elucidate whether they can be developed into therapeutic agents.

 

  • References

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