Planta Med 2019; 85(18): 1515-1516
DOI: 10.1055/s-0039-3399965
Main Congress Poster
Poster Session 2
© Georg Thieme Verlag KG Stuttgart · New York

Anti-staphylococcal activity of Myristica hypargyraea and Myristica inutilis from Samoa

M Houdkova
1   Department of Crop Sciences and Agroforestry, Faculty of Tropical AgriSciences, Czech University of Life Sciences Prague,, Kamycka 129, 165 00 Suchdol, Prague 6, Czech Republic
,
J Wong Soon
2   Scientific Research Organisation of Samoa,, P.O. Box 6597, Nafanua, Western, Apia, Samoa
,
T Foliga
3   Strengthening Multi Sectoral Management of Critical Landscapes in Samoa (SMSMCL) Project, Ministry of Natural Resources of Environment,, Apia, Samoa
,
P Novy
4   Food and Natural Resources, Czech University of Life Sciences Prague,, Department of Food Science, Faculty of Agrobiology, Kamycka 129, 165 00 Suchdol, Prague 6, Czech Republic
,
L Kokoska
1   Department of Crop Sciences and Agroforestry, Faculty of Tropical AgriSciences, Czech University of Life Sciences Prague,, Kamycka 129, 165 00 Suchdol, Prague 6, Czech Republic
› Author Affiliations
Further Information

Publication History

Publication Date:
20 December 2019 (online)

 

Staphylococcus aureus is a human pathogen colonizing especially skin and respiratory tract. This bacteria has a harmful potential to cause a variety of community and hospital-acquired infections. Over the years, S. aureus strains resistant to commonly used antibiotics have been reported, which complicates the staphylococcal infections’ treatment [1]. Various plant-derived products, such as Melaleuca alternifolia essential oil, are used for elimination of S. aureus in clinical practice [2]. Therefore, plant compounds and their mixtures (e.g. extracts) are still perspective materials for the development of new anti-staphylococcal agents. Since the antimicrobial properties of some Myristica sp. have already been reported [3], we decided to evaluate growth-inhibitory effects of seed and aril hexane extracts from two Samoan indigenous plant species Myristica hypargyraea A.Gray and Myristica inutilis Rich ex A.Gray, against twelve S. aureus strains including antibiotic-resistant forms using the broth microdilution method [4].

In this study, all plant extracts tested showed a certain degree of anti-staphylococcal effect with minimum inhibitory concentrations (MICs) ranging from 8 to 1,024 µg/mL. The aril extract of M. hypargyraea possessed the highest antibacterial activity against S. aureus ATCC 33591 and three clinical isolates with a MIC value of 8 µg/mL.

Our results suggest potent antimicrobial properties of seed and aril extracts from M. hypargyraea and M. inutilis that could be used by the pharmaceutical industry for the treatment of skin and respiratory infections caused by S. aureus. However, further research focused on chemical analysis, cytotoxic effects and in vivo evaluation is necessary to be carried out.

 

  • References

  • 1 Oliveira D, Borges A, Simoes M. Staphylococcus aureus toxins and their molecular activity in infectious diseases. Toxins 2018; 10 (06) : 252
    CrossrefPubMedGoogle Scholar
  • 2 Kokoska L, Kloucek P, Leuner O, Novy P. Plant-derived products as antibacterial and antifungal agents in human health care. Curr Med Chem 2019; 26: 1
    CrossrefPubMedGoogle Scholar
  • 3 Narasimhan B, Dhake AS. Antibacterial principles from Myristica fragrans seeds. J Med Food 2006; 9 (03) : 395
    CrossrefPubMedGoogle Scholar
  • 4 Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing. CLSI 2015 Twenty-fifth informational supplement M100-S25. Wayne (PA).
    PubMedGoogle Scholar