Planta Med 2019; 85(18): 1475-1476
DOI: 10.1055/s-0039-3399865
Main Congress Poster
Poster Session 1
© Georg Thieme Verlag KG Stuttgart · New York

Chemical compositions from Biscogniauxia sp. PK15-040 fungus

A Churat
1   Natural Products Research Unit, Centre of Excellence for Innovation in Chemistry (PERCH-CIC), Department of Chemistry, Faculty of Science, Khon Kaen University,, Khon Kaen, 40002, Thailand
,
W Mongkolthanaruk
2   Department of Microbiology, Faculty of Science, Khon Kaen University,, Khon Kaen, 40002, Thailand
,
N Suwannasai
3   Department of Microbiology, Faculty of Science, Srinakharinwirot University,, Bangkok, 10110, Thailand
,
N Wangsawat
4   Department of Biology, Faculty of Science, Srinakharinwirot University,, Bangkok, 10110, Thailand
,
S McCloskey
1   Natural Products Research Unit, Centre of Excellence for Innovation in Chemistry (PERCH-CIC), Department of Chemistry, Faculty of Science, Khon Kaen University,, Khon Kaen, 40002, Thailand
› Author Affiliations
Further Information

Publication History

Publication Date:
20 December 2019 (online)

 

The genus Biscogniauxia, which was once a member of wood-decaying fungi Xylariaceae family, has been resurrected and has become a member of new Graphostromataceae family. This fungus is naturally found on the bark, trunks, and branches of shrubs and trees [1]-[3]. Unlike its previous co-family, Xylaria genus, only a few reports on natural products were published from B. spp. [3]-[4]. The objective of this research is to investigate the chemical compositions from Biscogniauxia sp. PK15-040 fungus collected from the Phu Khieo Wildlife Sanctuary, Thailand. The fungus was identified by its morphological characteristics and molecular data. It was cultivated in PDB medium for 6 weeks and purified by chromatographic methods. Its structures were established by the interpretation of spectroscopic data including 1D and 2D NMR, and IR.

Fifteen compounds were isolated and categorised into eight classes of compounds, including three guaiane sesquiterpenes, pogostol (1), xylaranone (2), and xylaranol B (3); two mellein derivatives, 3,5-dimethyl-8-hydroxy-3,4-dihydroisocoumarin (4) and 3,5-dimethyl-8-methoxy-3,4-dihydroisocoumarin (5); two pyrone derivatives (6-7); two cyclodipeptides (8-9); two isopimarane diterpenes (10-11); two steroids, ergosterol (12) and ergone (13); p-tyrosol (14) and a bergamotene derivative (15). The results indicate that Biscogniauxia sp. PK15-040 is an example of a marvellous source of diverse secondary metabolites and possibly diverse bioactive compounds, therefore we believe that B. spp. needs to be investigated further.

Zoom Image
Fig. 1 Nature of Biscogniauxia sp. PK15-040 and structures of some isolated metabolites.
 

  • References

  • 1 Wendt L, Benjamin E, Kuhnert E, Heitkämper S, Lambert C, Hladki AI, Romero AI, Luangsa-ard JJ, Srikitikulchai P, Persoh D, Stadler M. Resurrection and emendation of the Hypoxylaceae, recognized from a multigene phylogeny of the Xylariales. Mycol Progress 2018; 7: 115-154
    PubMedGoogle Scholar
  • 2 Whally AJS. The Xylariaceous way of life. Mycol Res 1996; 100: 897-922
    CrossrefPubMedGoogle Scholar
  • 3 Amand S, Langenfeld A, Blond A, Dupont J, Nay B, Prado S. Guaiane Sesquiterpenes from Biscogniauxia nummularia Featuring Potent Antigerminative Activity. J Nat Prod 2012; 75: 798-801
    CrossrefPubMedGoogle Scholar
  • 4 Cheng M-J, Wu M-D, Hsieh S-Y, Chen I-S, Yuan G-F. Secondary metabolites isolated from the fungus Biscogniauxia cylindrospora BCRC 33717. Chem Nat Compd 2011; 4: 527-530
    PubMedGoogle Scholar