Characterization of chemical constituents from Fissistigma polyanthoides stems

The Dao ethnic community in Vietnam traditionally uses Fissistigma polyanthoides stems for treating inflammation and arthritis, as well as recuperating women after childbirth. The present study was conducted to provide detailed insights into the chemical composition of this medicinal plant, which has barely been studied in phytochemical terms in the past. Our efforts resulted in the isolation of 34 compounds, including 16 new and 18 known natural products. For structural elucidation, one- and two-dimensional NMR and MS techniques were used, the absolute configuration of compounds 4, 5, and 10 could be established by ECD calculation. Among all isolated compounds, fifteen terpenoids (1-15), fourteen flavonoids (16-29), one phenylpropanoid (30), and four alkaloids (31-34) were identified. Our results revealed that a substitution of the sesquiterpenoid scaffold with (2ʹ-O-trans-cinnamoyl)-β-ᴅ-glucopyranoside (1-9) are characteristic features of F. polyanthoides constituents.