Vet Comp Orthop Traumatol 2020; 33(02): 147-150
DOI: 10.1055/s-0039-3399525
Brief Communication
Georg Thieme Verlag KG Stuttgart · New York

Elevated Synovial Fluid Concentration of Monocyte Chemoattractant Protein-1 and Interleukin-8 in Dogs with Osteoarthritis of the Stifle

1  Department of Small Animal Medicine and Surgery, University of Georgia, Athens, Georgia, United States
,
Robert M. Gogal
2  Department of Veterinary Biosciences and Diagnostic Imaging, University of Georgia, Athens, Georgia, United States
,
Clinton George
2  Department of Veterinary Biosciences and Diagnostic Imaging, University of Georgia, Athens, Georgia, United States
,
MaryAnn Thaliath
1  Department of Small Animal Medicine and Surgery, University of Georgia, Athens, Georgia, United States
,
Steven C. Budsberg
1  Department of Small Animal Medicine and Surgery, University of Georgia, Athens, Georgia, United States
2  Department of Veterinary Biosciences and Diagnostic Imaging, University of Georgia, Athens, Georgia, United States
› Author Affiliations
Further Information

Publication History

13 March 2019

27 September 2019

Publication Date:
22 November 2019 (online)

Abstract

Chemokines such as monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) have been shown to cause monocyte and natural killer cell chemotaxis and polymorphonuclear cell chemotaxis, respectively. Additionally, MCP-1 signalling has been implicated in modulating pain. Elevated synovial fluid concentrations of MCP-1 and IL-8 have been demonstrated in humans with osteoarthritis, but currently there are no studies evaluating synovial MCP-1 or IL-8 concentrations in dogs. Additionally, there are no canine studies evaluating the correlation between these chemokines and caregiver perceived pain and mobility, as measured by the clinical metrology instrument, Liverpool Osteoarthritis in Dogs. This study documented elevated synovial fluid concentrations of IL-8 and MCP-1 in the stifle of dogs with secondary osteoarthritis compared with normal stifles. However, this study found no correlation between MCP-1 or IL-8 and Liverpool Osteoarthritis in Dogs or radiographic severity of osteoarthritis.

Authors' Contributions

Stephanie A. Kleine, Robert M. Gogal and Steven C. Budsberg contributed to conception of study, study design, acquisition of data and data analysis and interpretation. Clinton George and MaryAnn Thaliath contributed to study design and acquisition of data. All authors drafted, revised and approved the submitted manuscript.