Journal of Pediatric Infectious Diseases 2020; 15(03): 123-128
DOI: 10.1055/s-0039-1700955
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Evaluation of Platelet Activity Markers in Prognostic Value of Children with Crimean-Congo Hemorrhagic Fever

Ahmet Sami Güven
1  Department of Pediatrics, Meram Medical Faculty, Necmettin Erbakan University, Konya, Turkey
,
Fatma Duksal
2  Department of Pediatrics, Meram Training and Research Hospital, Konya, Turkey
,
Özge Metin Akcan
3  Division of Pediatric Infectious Diseases, Department of Pediatrics, Meram Medical Faculty, Necmettin Erbakan University, Konya, Turkey
,
Utku Aygüneş
4  Division of Pediatric Hematology, Department of Pediatrics, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey
,
Mehmet Burhan Oflaz
1  Department of Pediatrics, Meram Medical Faculty, Necmettin Erbakan University, Konya, Turkey
› Author Affiliations
Further Information

Publication History

15 August 2019

25 November 2019

Publication Date:
08 January 2020 (online)

Abstract

Objective The aim of this study is to investigate the prognostic value of platelet (PLT) activity markers in children with Crimean-Congo hemorrhagic fever (CCHF) and compare results with healthy controls.

Materials and Methods A total of 135 patients with CCHF and 100 healthy children were included in this retrospective study. Mean age was 12.4 ± 3.3 years in CCHF group, and 92 patients were male. We measured PLT count, mean platelet volume (MPV), platelet distribution width (PDW), and mean platelet mass (MPM) as PLT activity markers.

Results A statistically significant decrease in MPM and PLT, and significantly higher levels of PDW and activated partial thromboplastin time (aPTT) and no significant difference in MPV were observed in patients with CCHF compared with controls. Although there were no significant differences between the severe and nonsevere CCHF groups in term of MPV and PDW, the MPM value was significantly decreased in severe patients (p < 0.001). Furthermore, MPM values were inversely correlated with aPTT (r = −0.617, p = 0.015), and positively correlated with PLT (r = 0.703, p < 0.001) which are considered likely to be indicators of disease severity. Multivariate logistic regression analysis revealed MPM as an independent risk factor for severe disease.

Conclusion Our study demonstrated that MPM values were decreased in severe cases compared with nonsevere in children with CCHF. The MPM as an indicator of PLT activation at the time of diagnosis in children with CCHF can be used as a prognostic index for disease severity.