CC BY-NC-ND 4.0 · Organic Materials 2019; 01(01): 038-042
DOI: 10.1055/s-0039-1700849
Short Communication
The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/). (2019) The Author(s).

Application of Cationic Conjugated Polymer–Outer Membrane Vesicle Complexes in Inhibiting Red Blood Cell Aggregation

Ping He
a  Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China
,
Endong Zhang
a  Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China
b  School of Chemistry and Chemical Engineering, University of Chinese Academy of Sciences, Beijing, China
,
Ruilian Qi
a  Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China
,
Fengting Lv
a  Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China
,
a  Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China
b  School of Chemistry and Chemical Engineering, University of Chinese Academy of Sciences, Beijing, China
,
a  Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China
b  School of Chemistry and Chemical Engineering, University of Chinese Academy of Sciences, Beijing, China
› Author Affiliations
Funding Information: The authors would like to thank the National Natural Science Foundation of China (21773268, 21533012, and 21661132006) for financial support.
Further Information

Publication History

Received: 06 August 2019

Accepted after revision: 16 September 2019

Publication Date:
28 November 2019 (online)


Abstract

Cationic conjugated polymers (CCPs) have been attracting a lot of attention in biomedical applications because of their good photoelectric properties and good cell viability. However, positively charged components may reduce the electrostatic repulsion among red blood cells (RBCs) and induce RBC aggregation, which may lead to thrombus. Herein, in this work, we prepared the complexes of CCPs and outer membrane vesicles (OMVs) to inhibit RBC aggregation induced by CCPs and improve the biocompatibility of CCPs. A poly(fluorene-co-phenylene) derivative (PFP), a poly(p-phenylenevinylene) derivative (PPV), and a poly(thiophene) derivative (PMNT) were chosen as the model CCPs, and OMVs were used as the representative of a cell membrane. The CCP–OMV complexes were formed mainly driven by electrostatic interactions. Besides, the electrostatic CCP–OMV complexes were proved to be able to prevent the RBC aggregation induced by CCPs while maintaining the hydrophobic interactions between CCPs and RBCs.

Supporting Information

Supporting information for this article is available online at https://doi.org/10.1055/s-0039-1700849.


Supporting Information

 
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